Sanish Sathyan, Ph.D.

Research Assistant Professor

Email: sanish.sathyan@stonybrookmedicine.edu

Location: Stony Brook University,101 Nicolls Road, Stony Brook, NY 11794

Area of Research

Aging biology; longevity; frailty; dementia; human genetics; proteomics of aging and age-associated disorders; aging clock and phenotype prediction.

Education and Training

Education:

Postgraduate Training/Research:

Master of Science in Microbiology:

Dept. of Biotechnology & Microbiology, School of Life Sciences, Kannur University, Kerala, India.

Our research primarily focuses on understanding the biology of aging, with a particular emphasis on frailty, dementia, and other age-associated phenotypes. Aging is a major risk factor for numerous complex diseases that impact health span. In the realm of proteomics, we have conducted one of the first largest studies exploring plasma proteomic changes related to aging, identifying novel pathways and proteins. This work has led to the development of Proteomic Aging Clocks (PAC), which predict biological age based on plasma protein subsets. Our PAC has proven to be a significant determinant of health outcomes, including frailty, complex diseases, and mortality.

Frailty, a geriatric syndrome, is characterized by decreased physiological reserve and increased vulnerability to adverse outcomes. Our studies have focused on understanding the biological underpinnings of frailty, identifying numerous proteins associated with frailty and pathways enriched in lipid metabolism, musculoskeletal development, and cellular organization. We have also investigated the biological basis of Motoric Cognitive Risk (MCR) syndrome, a pre-dementia condition marked by slow gait and subjective cognitive complaints. Our studies have demonstrated the impact of biological age acceleration on dementia progression. We also deciphered genetic as well as proteomic basis of this predementia syndrome.

We are currently focused on deciphering the genetic underpinnings of Motoric Cognitive Risk syndrome using multicohort consortium. Another main focus is the development of better predictors of aging and frailty phenotypes using genetics, epigenetics, and proteomics approaches.

Sathyan, S., Ayers, E., Adhikari, D., Gao, T., Milman, S., Barzilai, N., & Verghese, J. (2023). Biological Age Acceleration and Motoric Cognitive Risk Syndrome. Annals of Neurology. PMID: 36843279

Sathyan, S., Ayers, E., Gao, T., Weiss, E. F., Milman, S., Verghese, J., & Barzilai, N. (2020). Plasma proteomic profile of age, health span, and all‐cause mortality in older adults. Aging cell, e13250. PMID: 33089916

Sathyan, S., Ayers, E., Gao, T., Milman, S., Barzilai, N., and Verghese, J. (2020). Plasma proteomic profile of frailty. Aging cell, 19(9), e13193. PMID: 32762010

Lehallier, B., Gate, D., Schaum, N., Nanasi, T., Lee, S.E., Yousef, H., Losada, P.M., Berdnik, D., Keller, A., Verghese, J., Sathyan, S., Franceschi, C.,Milman, S.,Barzilai, N., and Wyss-Coray, T. (2019). Undulating changes in human plasma proteome profiles across the lifespan. Nature medicine, 25(12), pp.1843-1850. PMID: 31806903

Sathyan, S., Wang, T., Ayers, E. and Verghese, J. Genetic basis of motoric cognitive risk syndrome in the Health and Retirement Study. Neurology 92, 13 (2019): e1427-e1434. PMID: 30737336

Sathyan, S., Barzilai, N., Atzmon, G., Milman, S., Ayers, E., & Verghese, J. Association of anti-inflammatory cytokine IL10 polymorphisms with motoric cognitive risk syndrome in an Ashkenazi Jewish population. Neurobiology of aging, 5(2017). 8, 238-e1. PMID: 28705468

Hamilton Oh H, Jarod Rutledge J, Nachun D, Pálovics R, Abiose O, Moran-Losada P, Channappa D, Urey D Y, Kim K, Sung Y J, Wang L, Timsina J, Western D, Liu M, Kohlfeld P, Budde J,  Wilson E N, Guen Y, Maurer T M, Haney M, Yang A C, He Z, Greicius M D, Andreasson K I, Sathyan S, Weiss E F, Milman S, Barzilai N, Cruchaga C, Wagner A, Mormino E, Lehallier B,  Henderson V W, Longo F M, Montgomery S B, Wyss-Coray T. (2023). Organ aging signatures in the plasma proteome track health and disease. Nature, 624(7990), 164-172.  PMID: 38057571

Complete List of Published Work 

https://www.ncbi.nlm.nih.gov/myncbi/sanish.sathyan.1/bibliography/public/