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Senior Research Support Specialist
e-mail: Liqun.Huang@stonybrookmedicine.edu
Ms. Huang received her M.S. and B.S. from Wuhan University, P. R. China. She has worked on screening of the viral tegument protein pp71 cellular interacting partners using PCR, TA cloning and sequencing techniques in human Cytomegalovirus (HCMV) based on yeast two-hybrid system, as well as on generating of mutated HCMVs in which the pp71 was deleted or that contained point mutations to understand its function on viral gene expression and replication using bacterial artificial chromosome (BAC) technique. She also worked on genome-based identification of cancer genes cooperated with RUNX1 gene in the progress of acute myeloid leukemia (AML) by retroviral integration using IPCR, TA cloning, Southern Blot, and database search. Ms. Huang has extensive experience in molecular biology, ProteinChip Array, and DNA microarray technology.
Currently Ms. Huang is working on evaluating novel agents for their anti-cancer and inflammatory properties, using various in vitro and in vivo models, focusing on arthritis and on colon and breast cancer.
Selected Publications:
- Zhou H, Huang L, Sun Y, Rigas, B. Nitric oxide-donating aspirin inhibits growth of pancreatic cancer cells through redox-dependent signaling. Cancer Lett, in press.
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- Zhou H, Huang L, Sun Y, Rigas, B. Nitric oxide-donating aspirin inhibits growth of pancreatic cancer cells through redox-dependent signaling. Cancer Lett, in press. To view pdf click here.
- Huang L, Osato M, Yanagida M, Yamashita N, Ito Y. The myeloid features of BXH2 leukemias may result from lack of one copy of repetitive sequence in the long terminal repeat (LTR) viral enhancer. International Journal of Hematology,
85(2):170-172, 2007.
- Zhou L, Beuerman RW, Huang L, Barathi A, Foo YH, Li SF, Chew FT, Tan D. Proteomic analysis of rabbit tear fluid: Defensin levels after an experimental corneal wound are correlated to wound closure. Proteomics, 7(17): 3194-206, 2007.
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- Asou N, Yanagida M, Huang L, Yamamoto M, Shigesada K, Mitsuya H, Ito Y, Osato M. Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia. Blood, 109(9): 4023-4027, 2007.
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- Yamashita N, Osato M, Huang L, Yanagida M, Kogan SC, Iwasaki M, Nakamura T, Shigesada K, Asou N, Ito Y. Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice. British Journal of Hematology, 131(4): 495-507, 2005.
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- Yanagida M, Osato M, Yamashita N, Huang L, Jacob B, Wu F, Cao X, Nakamura T, Yokomizo T, Takahashi S, Yamamoto M, Shigesada K, Ito Y. Increased dosage of RUNX1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice. Oncogene, 24(28): 4477-85, 2005 .
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- Zhou L, Huang L, Beuerman RW, Grigg WE, Li SFY, Chew FT, Ang L, Stern ME, Tan D. Proteomic Analysis of Human Tears: Defensin Expression after Ocular Surface Surgery. J. Proteome Research 3(3): 410-416, 2004
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- Ng HT, Fang AP, Huang L, Li SFY. Protein microarrays on ITO surfaces by a direct covalent attachment scheme. Langmuir, 18 (16): 6324-6329 AUG 6 2002.
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- Eun AJC, Huang L , Chew FT, Li SFY, Wong SM. Detection of two orchid viruses using quartz crystal microbalance-based DNA biosensors. Phytopathology 92 (6): 654-658 JUN 2002. To view pdf click here.
- Eun AJC, Huang L, Chew FT, Li SFY, Wong SM, Detection of two orchid viruses using quartz crystal microbalance (QCM) immunosensors. J. Virological Methods. 99(1-2):71-9, 2002. To view pdf click here.
- Zhou XC, Huang L , Li SFY. Microgravimetric DNA sensor based on quartz crystal microbalance: comparison of oligonucleotide immobilization methods and the application in genetic diagnosis. Biosens. & Bioelectron. 16(2): 85-95, 2001. To view pdf click here.
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