Gang Xie

Gang XieGang Xie
Research Scientist

e-mail: Gang.Xie@stonybrookmedicine.edu

Dr. Xie received his BS in Biochemistry from Nanjing University, China and his PhD in Chemistry from South Dakota State University. During his postdoctoral study at Montana State University, he investigated the molecular mechanism of iron acquisition by human pathogens for vaccine development. Dr. Xie is currently working on the metabolism and pharmacokinetics of novel anti-cancer agents under study in our lab. He is also investigating their mechanism of action using chemical methodologies. 

Selectected Peer-Reviewed Publications:

  • Xie G, Wong CC, Cheng KW, Huang L, Constantinides PP, Rigas B (2012).  Regioselective oxidation of phospho-NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: implications for their pharmacokinetic preoperties and safety. British Journal of Pharmacology 167(1): 222-232.
  • Xie G, Nie T, Mackenzie GG, Sun Y, Huang L, Ouyang N, et al. (2012). The metabolism and pharmacokinetics of phospho-sulindac (OXT-238) and the effect of difluoromethylornithine.  British Journal of Pharmacology 165(7):2152-2166.
  •  Xie G, Wong CC, Cheng KW, Huang L, Constantinides PP, Rigas B (2012). In Vitro and In Vivo Metabolic Studies of Phospho-aspirin (MDC-22). Pharmaceutical Research.
  •  Xie G, Sun Y, Nie T, Mackenzie GG, HuangL, Kopelovich L et al. (2011). Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: efficacy, metabolism, and pharmacokinetics in mouse models.  The Journal of Pharmacology and Experimental Therapeutics 337(3):876-886. 
  • Schepetkin IA, Xie G, Jutila M and Quinn MT.  2009 Complement-fixing activity of humic substances from Shailajit and other natural sources.  Phytotherapy Research, 23:373-384.
           To view pdf click here
  • Xie G, Liu M. Zhu H. and Lei B. 2008 Esterase of Streptococcus equi, SeE, is a

      novel nonspecific carboxylic ester hydrolase.  FEMS Microbiology letters,

      289(2):181-6.

        To view pdf click here.

  • Zhu H, Xie G, Liu M, Olson JS, fabian M. dooley DM, and Lei B. 2008.  Pathway

       for heme uptake from human methemoglobin by the Iron-Regulated Surface

       Determinants (Isd) system of Staphyloccoccus aureus.  Journal of Biological

       Chemistry, 283:18450-18460.

         To view pdf click here.

  • Xie G, Schepetkin IA, Siemsen DW, Kirpotina LN, Wiley JA, Quinn MT.  2008

       Fractionation and characterization of biologically-active polysaccharides from

       Artemisia tripartita.  Phytochemistry, 69(6):1359-71

         To view pdf click here.

  • Schepetkin IA, XIE G, Kirpotina LN, Klein RA, Jutila MA, Quinn MT. 2008

       Macrophage immunomodulatory activity of polysaccharides isolated from

       Opuntia polyacantha.  International Immunopharmacology, 8(10):1455-66.

         To view pdf click here.

  • Xie G, Schepetkin IA, Quinn MT. 2007.  Immunomodulatory activity of acidic

        polysaccharides isolated from Tanacetum vulgare.  L. International

        Immunopharmacology, 7(13):1639-50.

           To view pdf click here.

  • Xie G,and West TP.  2006.  citric acid production by Aspergillus niger on wet

          corm distillers grains.  Letters in Applied Microbiology, 43.269-273