Labros Meimetis, Ph.D.
Assistant Professor of Radiology
Education:
- Postdoc, Harvard Medical School/MGH, Boston, MA, 2016
- Ph.D. University of British Columbia, Vancouver, Canada, 2012
- BSc. Simon Fraser University, Burnaby, Canada, 2006
Patents:
- Meimetis, L.G.; Carlson, J.; Weissleder, R. “Bioorthogonal turn-on probes” US20160121002A1.
- Meimetis, L.G.; Nodwell, M.B.; Wang, X.; Andersen, R.J. “Decahydrobenzofluorene and dodecahydrofluorenoazepine derivatives as SHIP1 modulators and their preparation” US9000050B2.
Awards and Recognitions:
Dr. Labros Meimetis is Assistant Professor of Radiology at Stony Brook Medicine. He has received the Catacosinos Cancer Translational Researcher Award (2021).
Research:
Dr. Meimetis research interests include:
- Developing drugs and biologics to address escape pathways in tumors that result in current treatment strategies to fail in clinical trials and at best provide modest survival times in patients administered with approved drugs.
- Therapies to overcome the following pain points will be developed:
- Heterogeneous tumors
- Poor solid tumor penetration using BiTE, bispecific and CAR-T therapies.
- To enable enabling novel drug discovery
- Eliciting tumor immunogenicity
- Adjuvants for enhanced immune cell penetration in solid tumors
- High-potency warheads for antibody drug conjugates for low TAA copy number
Molecular imaging will play a key role in advancing these programs and will encompass Positron Emission Tomography (PET) using 18F, 89Zr, 68Ga and 44Sc labelled probes in preclinical animal models to determine immune cell distribution to identify the most suitable drug candidates to advance to the next round of testing.
To see more access Dr. Meimetis' lab website.
Publications:
- Positron Emission Tomography Imaging of Staphylococcus aureus Infection Using a Nitro-Prodrug Analogue of 2-[18F]F-p-Amino benzoic Acid. Li Y, Daryaee F, Yoon GE, Noh D, Smith-Jones PM, Si Y, Walker SG, Turkman N, Meimetis L, Tonge PJ. ACS Infect Dis. 2020 Aug 14; 6(8):2249-2259. Doi: 10.1021/acsinfecdis.0c00374. Epub 2020 Jul 31. PMID: 32672928
A full list of articles published by Dr. Meimetis is available here on PubMed.
Contact Information:
Stony Brook Medicine
Department of Radiology
HSC Level 4, Room 092
Stony Brook, NY 11794-8460
Phone: 631-444-5400
Fax: 631-444-6450
Email: Labros.Meimetis@stonybrookmedicine.edu
