Chengfeng Yang, PhD

Chengfeng Yang, PhD

Professor

Department of Pathology

Stony Brook Cancer Center

MART 7M-0834

631-216-2929

Chengfeng.Yang@stonybrookmedicine.edu

 

Research Interest: RNA dysfunction in carcinogenesis and resistance to cancer therapies 

Research Summary: One of milestones achieved in biology research during the past three decades is the view change on RNA biology and function. The demonstration of important functions of microRNAs (miRNAs, a sub-class of small non-coding RNAs) in regulating gene expression in 1993 challenged the central dogma of molecular biology. The recognition of critical roles of RNA m6A methylation in physiology and pathogenesis during the past decade further revolutionized our understanding of RNA biology and function. With the completion of the human genome project, it is now believed that human genome is pervasively transcribed, and a large portion of the genome is transcribed as non-coding RNAs especially as long non-coding RNAs (lncRNAs). However, the current knowledge on lncRNA function in cancer is limited. The research in Yang lab is focused on investigating the role and mechanism of RNA abnormal expression and posttranscriptional modifications in cancer initiation (carcinogenesis), progression (metastasis) and therapeutic resistance. The goal of our research is to identify dysfunctional RNA molecules as cancer diagnostic markers and therapeutic targets to reduce cancer risk and improve human health.

Graduate student positions are available to study the mechanism of carcinogenesis.

Education                                                                            Degree                                                                 Year (s)

 

Bachelor of Medicine,                                                       MD                                                                         1986

Tongji Medical University,

Wuhan, Hubei China

 

Master of Environmental Health,                                     MS                                                                         1991

Tongji Medical University, Wuhan,

Hubei China       

 

Molecular Toxicology/Carcinogenesis,                             PhD                                                                        2001

National University of Singapore,

Singapore                                           

 

Residency and Fellowship Training

 

2000-2001 Postdoctoral Fellow, Department of Environmental Medicine, School of Medicine, New York University, New York University, NY

2001-2006 Postdoctoral Fellow, Department of Pharmacology School of Medicine, University of Pennsylvania, Philadelphia, PA

 

Current and Previous Appointments

 

2007-2007 Assistant Professor (Research Track) Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, PA

2007-2013 Assistant Professor (Tenure Track) Department of Physiology, Center for Integrative Toxicology, Michigan State University, East Lansing, MI

2013-2016 Assistant Professor with tenure Department of Physiology, Institute for Integrative Toxicology, Michigan State University, East Lansing, MI

2016-2021 Professor with tenure, Department of Toxicology and Cancer Biology Center for Research on Environmental Diseases, Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY

2021-2023 Professor, Division of Cancer Biology, Department of Medicine, Metro Health Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH

2021-2023 Member, Molecular Oncology Research Program, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH