Mario Shields, PhD
Associate Professor
Stony Brook Cancer Center
Basic Sciences Tower, Level 9
Stony Brook Medicine
Stony Brook, NY 11794-8691
Tel: (631) 216-9350
E-mail: Mario.shields@stonybrook.edu
Research Interests:
Pancreatic Tissue Injury, Regeneration and Tumorigenesis
My laboratory investigates the mechanisms of development and progression of diseases affecting the exocrine pancreas, such as pancreatitis and pancreatic cancer. Our major focus is on an NIH-funded project investigating the role of G-protein regulated signaling in tumor metabolism and inflammation. We are also investigating how inflammation and loss of cell polarity impact pancreatitis and pancreatic cancer development and progression. We employ genetically engineered mouse models, complemented by a broad range of molecular, cell biology, histological, and omics methods.
| Education: | |||
| Institution and Location | Degree | Year | Field of Study |
| University of the West Indies, Jamaica | BSc | 2003 | Chemistry/Biochemistry |
| University of the West Indies, Jamaica | MPhil | 2007 | Chemistry |
| Northwestern University, Evanston IL | PhD | 2012 | Life Science/Cancer |
| Cold Spring Harbor Laboratory, Cold Spring Harbor, NY | Postdoc | 2018 | Cancer |
Positions and Employment: |
|
| 2018-2023 | Research Assistant Professor, Feinberg School of Medicine, Northwestern University, Chicago, IL |
| 2023-2024 | Research Associate Professor, Feinberg School of Medicine, Northwestern University, Chicago, IL |
| 2024-present | Associate Professor, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY |
Honors (selected): |
|
|
2023 Biden NCI Moonshot Scholar Award (NIH R01 Award) 2023 Lurie Cancer Center Diversity Scholar Award 2021 American Association for Cancer Research (AACR) Minority and Minority-Serving Institution Faculty Scholar in Cancer Research Award 2021 American Pancreatic Association (APA) Poster of Distinction Award 2020 American Pancreatic Association (APA) Young Investigator Pancreatitis Grant Award 2017 Nomination to Sigma Xi, The Scientific Research Honor Society 2015 AACR-Bayer Healthcare Basic Research Postdoctoral Fellowship 2014 Forbeck Scholar Award, William Guy Forbeck Research Foundation 2014 AACR-Aflac Travel Award and Poster Award 2011 Outstanding Award for poster presentation: Gordon Conference on Matrix Metalloproteinase 2011 1st Place for poster competition, NU Feinberg School of Medicine Lewis Landsberg Research Day 2003 University of the West Indies Scholarship for Graduate Studies and Research, 2003 Garfield Sadler Award for Undergraduate Inorganic Chemistry, UWI 2002 Pavelich/Honkan Prize for Undergraduate Chemistry, UWI 2000 Emancipation Scholarship (National Award), Ministry of Education and Youth, Jamaica |
|
Other Experience and Professional Memberships (selected): |
|
|
American Association for Cancer Research |
|
|
American Pancreatic Association |
|
|
Sigma Xi |
|
Selected Publications: |
|
| 1. |
Shields MA*, Metropulos AE, Spaulding C, Alzahrani KA, Hirose T, Ohno S, Pham TND, Munshi HG. BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice with Loss of the Polarity Protein Par3. Cell Mol Gastroenterol Hepatol. 2024 Aug 10;18(5):101389. doi: 10.1016/j.jcmgh.2024.101389. Online ahead of print.* co-corresponding author |
| 2. |
Becker JH, Metropulos AE, Spaulding C, Marinelarena AM, Shields MA, Principe DR, Pham TD, Munshi HG. Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer. Cancer Res. 2024 Aug 13. doi: 10.1158/0008-5472.CAN-23-3574. Online ahead of print. |
| 3. |
Pham TD, Metropulos AE, Mubin N, Becker JH, Shah D, Spaulding C, Shields MA, Bentrem DJ, Munshi HG. Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells. Mol Cancer Ther. 2024 Aug 20. doi: 10.1158/1535-7163.MCT-23-0833. Online ahead of print. |
| 4. |
Pham TN, Spaulding C, Shields MA, Metropulos AE, Shah DN, Khalafalla MG, Principe DR, Bentrem DJ, Munshi HG. Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity.JCI Insight. 2022 May 9;7(9):e152731. doi: 10.1172/jci.insight.152731. |
| 5. |
Shields MA*, Spaulding C, Metropulos AE, Khalafalla MG, Pham TND, Munshi HG. Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin. Cell Rep. 2022 Mar 1;38(9):110441. doi: 10.1016/j.celrep.2022.110441. *co-corresponding author |
| 6. |
Barth ND, Subiros-Funosas R, Mendive-Tapia L, Duffin R, Shields MA, Cartwright JA, Henriques ST, Sot J, Goñi FM, Lavilla R, Marwick JA, Vermeren S, Rossi AG, Egeblad M, Dransfield I, Vendrell M. A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis. Nat Commun. 2020 Aug 12;11(1):4027. doi: 10.1038/s41467-020-17772-7. |
| 7. |
Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, Küttner V, Bružas E, Maiorino L, Bautista C, Carmona EM, Gimotty PA, Fearon DT, Chang K, Lyons SK, Pinkerton KE, Trotman LC, Goldberg MS, Yeh JT, Egeblad M. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science. 2018 Sep 28;361(6409):eaao4227. doi: 10.1126/science.aao4227. |
| 8. |
Shields MA, Ebine K, Sahai V, Kumar K, Siddiqui K, Hwang RF, Grippo PJ, Munshi HG. Snail cooperates with KrasG12D to promote pancreatic fibrosis. Mol Cancer Res. 2013 Sep;11(9):1078-87. doi: 10.1158/1541-7786.MCR-12-0637. Epub 2013 Jun 12. |
| 9. |
Shields MA, Dangi-Garimella S, Redig AJ, Munshi HG. Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression. Biochem J. 2012 Jan 15;441(2):541-52. doi: 10.1042/BJ20111240. |
Media:
