Yubin Miao, PhD

Yubin Miao, PhD

Professor, Department of Radiology

Office: (631)-216-9290

Email: Yubin.miao@stonybrookmedicine.edu

Address:
Stony Brook Cancer Center
MART Level 7, Rm 7M-0828
Lauterbur Drive, Stony Brook, NY 11794

Education

BSc in Chemistry, Beijing Normal University, Beijing, P. R. China, 1992

MS in Radiopharmaceutical Chemistry, Beijing Normal University, Beijing, P. R. China, 1994

PhD in Radiopharmaceutical Chemistry, Beijing Normal University, Beijing, P. R. China, 1997

Postdoctoral Fellow in Peptide Radiopharmaceutical, University of Missouri-Columbia, MO, USA, 2003

Research Interests

The research interest in Dr. Miao‘s laboratory focuses on developing novel radiolabeled peptides for cancer (melanoma, breast and prostate cancers) diagnosis and treatment. Specifically, we are using radiolabeled peptides to target G protein-coupled receptors (GPCRs) that are over-expressed on cancer cells for cancer detection and therapy. Radiolabeled peptides are attractive probes for cancer imaging and therapy due to their specific nanomolar binding with the GPCRs on cancer cells. Radiolabeled peptides can selectively deliver diagnostic and therapeutic radionuclides to cancer cells through peptide-receptor interactions for imaging and therapy. Hence, malignant tumors can be detected non-invasively by imaging modalities (SPECT or PET) through the collection of photons generated from diagnostic radionuclides. Moreover, malignant tumors can be effectively treated by targeted radiation yielded from therapeutic radionuclides delivered by peptides.

Research Program

Imaging, Biomarker Discovery and Engineering Sciences

  • Postdoctoral Fellowship, University of Missouri-Columbia, 1999-2001
  • Society of Nuclear Medicine Radiopharmaceutical Science Council Young Investigator Award, 2002
  • American Association of Colleges of Pharmacy New Investigator Award, 2007
  • Department of Defense Breast Cancer Research Program Idea Award, 2008
  • Top newsmaker of 2011 by New Mexico Business Weekly, 2011
  • STC.UNM Innovation Award, 2014
  • The Academy for Radiology & Biomedical Imaging Research Distinguished Investigator Award, 2019
  • Yubin Miao, Haixun Guo. US Patent US 11,160,887, November 2021
  • Yubin Miao, Haixun Guo. US Patent US 10,464,985 B2, April 2019
  • Yubin Miao, Haixun Guo. US Patent US 10,265,425 B2, April 2019
  • Yubin Miao. US Patent US 10,238,758, March 2019
  • Yubin Miao. US Patent US 10,047,135 B2, August 2018
  • Yubin Miao, Haixun Guo. US Patent US 9,493,537 B2, November 2016
  • Yubin Miao. US Patent US 9,463,255 B1, October 2016
  • Yubin Miao, Haixun Guo. US Patent US 9,393,330 B2, July 2016
  • Yubin Miao. US Patent US 9,180,214, November 2015
  • Yubin Miao, Jianquan Yang. US Patent US 9,005,575 B2, April 2015
  • Yubin Miao, Haixun Guo. US Patent US 8,986,651 B2, March 2015
  • Yubin Miao, Haixun Guo. US Patent US 8,603,435 B2, December 2013
  1. Claudia G. Chambers, Jing Wang, Tamer M. Sakr, Yubin Miao, Charles J. Smith. NOTA and NODAGA radionuclide complexing agents: versatile approaches for advancements in radiochemistry. Molecules 2025;30:2095. PMCID: PMC12113903.
  2. Zheng Qiao, Jingli Xu, Fabio Gallazzi, Darrell R. Fisher, Rene Gonzalez, Yubin Miao. The effect of ibuprofen as an albumin binder on melanoma targeting properties of 177Lu-labeled ibuprofen-conjugated alpha-melanocyte-stimulating hormone peptides. Molecular Pharmaceutics 2024; 21:4004-4011. PMCID: PMC11317992.
  3. Claudia Chambers, Broc Chitwood, Charles J. Smith, Yubin Miao. Elevating theranostics: the emergence and promise of radiopharmaceutical cell-targeting heterodimers for human cancers. iRadiology 2024;2:128-155. PMCID: PMC11067702.
  4. Zheng Qiao, Jingli Xu, Darrell R. Fisher, Rene Gonzalez, Yubin Miao. Introduction of a polyethylene glycol linker improves uptake of 67Cu-NOTA-conjugated lactam-cyclized alpha-melanocyte-stimulating hormone peptide in melanoma. Cancers 2023;15:2755. PMCID: PMC10216305.
  5. Zheng Qiao, Jingli Xu, Rene Gonzalez, Yubin Miao. Effects of polyethylene glycol and 8-aminooctanoic acid linkers on melanoma uptake of 99mTc-tricarbonyl-NOTA-conjugated lactam-cyclized alpha-MSH peptides. Bioconjugate Chemistry 2023;34:934-940. PMCID: PMC10192115.
  6. Zheng Qiao, Jingli Xu, Rene Gonzalez, Yubin Miao. Novel 64Cu-labeled NOTA-conjugated lactam-cyclized alpha-melanocyte-stimulating hormone peptides with enhanced tumor to kidney uptake ratios. Molecular Pharmaceutics 2022;19:2535-2541. PMCID: PMC10188253.
  7. Zheng Qiao, Jingli Xu, Rene Gonzalez, Yubin Miao. Novel Al18F-NOTA-conjugated lactam-cyclized alpha-melanocyte-stimulating hormone peptides with enhanced melanoma uptake Bioconjugate Chemistry 2022;33:982-990. PMCID: PMC10188279.
  8. Jingli Xu, Fabio Gallazzi, Darrell R. Fisher, Rene Gonzalez, Yubin Miao. The effect of albumin binding moiety on tumor targeting properties of 67Ga-labeled albumin binder-conjugated alpha-melanocyte-stimulating hormone peptides. Cancer Biotherapy and Radiopharmaceuticals 2022;37:47-55. PMCID: PMC8865629.
  9. Yubin Miao and Thomas P. Quinn. Advances in receptor-targeted radiolabeled peptides for melanoma imaging and therapy. Journal of Nuclear Medicine 2021;62:313-318. PMCID: PMC8049342.
  10. Jingli Xu, Zheng Qiao, Rene Gonzalez, Yubin Miao. Facile preparation of a novel Ga-67-labeled NODAGA-conjugated lactam-cyclized alpha-MSH peptide at room temperature for melanoma targeting. Bioorganic & Medicinal Chemistry Letters 2020;30:127627. PMCID: PMC7704577.
  11. Zheng Qiao, Jingli Xu, Rene Gonzalez, Yubin Miao. Novel 99mTc-Tricarbonyl-NOTA-conjugated lactam-cyclized alpha-MSH peptide with enhanced melanoma uptake and reduced renal uptake. Molecular Pharmaceutics 2020;17:3581-3588. PMCID: PMC7484323.
  12. Jingli Xu, Jianquan Yang, Rene Gonzalez, Darrell R. Fisher, Yubin Miao. Melanoma targeting property of Y-90-labeled lactam-cyclized alpha-melanocyte-stimulating hormone peptide. Cancer Biotherapy and Radiopharmaceuticals 2019;34:597-603. PMCID: PMC6856944.
  13. Jianquan Yang, Jingli Xu, Lina Cheuy, Rene Gonzalez, Darrell R. Fisher, Yubin Miao. Novel Pb-203-labeled lactam-cyclized alpha-melanocyte-stimulating hormone peptide for melanoma imaging. Molecular Pharmaceutics 2019;16:1694-1702. PMCID: PMC6443429.
  14. Brian D. Berman, Rebecca T. Pollard, Erika Shelton, Ramesh Karki, Peter Smith-Jones, Yubin Miao. GABAA receptor availability changes underlie symptoms in isolated cervical dystonia. Frontiers in Neurology 2018;9:188. PMCID: PMC5893646.
  15. Jianquan Yang, Jingli Xu, Rene Gonzalez, Thomas Lindner, Clemens Kratochwil, Yubin Miao. 68Ga-DOTA-GGNle-CycMSHhex targets the melanocortin-1 receptor for melanoma imaging. Science Translational Medicine 2018;10:eaau4445. PMCID: PMC6383514.

A complete list of publications can be found here
https://pubmed.ncbi.nlm.nih.gov/?term=Yubin+Miao&sort=date