Research Laboratories

  • Digital Radiological Imaging Laboratory (DRIL), led by Dr. Wei Zhao, is working to develop new detector technologies for medical imaging and to investigate their performance in advanced clinical applications. The group investigates imaging performance and design optimization for amorphous selenium flat-panel detectors for digital mammography and digital breast tomosynthesis, as well as advanced detector concepts for improved imaging performance at low dose and high frame rates
  • Laboratory for Imaging Research and Informatics (IRIS), led by Dr. Jerome Liang, has developed numerous algorithms for (1) reconstructions of quantitative single photon emission computed tomography (SPECT), high resolution positron emission tomography (PET) and low-dose computed tomography (CT), (2) segmentation of multi-spectral magnetic resonance (MR) and CT images, (3) registration of dynamically acquired MR scans from moving and deformable organs, and (4) feature extraction and classification for computer aided detection (CADe) and diagnosis (CADx).
  • Medical Image Research and Analysis (MIRA) Laboratory, led by Dr. Chuan Huang, conducts research in medical imaging technologies including Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Single Photo Emission Computed Tomography (SPECT), simultaneous PET/MRI and their applications in psychiatric disorders, neurological diseases, cancer, cardiac diseases, etc. This lab is particularly interested in imaging-guided precision medicine (treatment prediction, treatment response early detection, and medical imaging guided treatment selection) and understanding the biology using medical imaging.
     
  • Neurologic and Ophthalmic MRI Laboratory, led by Eric Muir, researches the development and application of MRI methods to investigate the anatomy, physiology, and function of the brain and the eye in both preclinical models and in humans. The lab has used sophisticated MRI techniques to investigate vascular dysfunction and pathophysiology of retinal diseases, including diabetic retinopathy, glaucoma, retinal degeneration, and neurological diseases, including Parkinson’s disease, diabetes, and hypertension.
  • Preclinical PET/SPECT/CT Laboratory, led by Dr. Paul Vaska. Our preclinical imaging facility also houses a trimodality PET/SPECT/CT (Siemens Inveon), a top-tier small-animal imaging platform located in a spacious lab in the main animal facility.  All 3 modalities can be accessed in a sequential manner, without removing the animal from the bed, thus providing a high degree of image registration. The PET component features a large field of view (9.9 cm transaxial x 12.7 cm axial), high spatial resolution (1.5 mm FWHM), and high sensitivity (6.8% coincidence).  The CT component provides anatomical information as well as attenuation correction for the PET.  It also has fully developed data processing software with all necessary quantitative corrections and multiple image reconstruction options (FBP, OSEM, MAP).  The lab includes a new Biodex Atomlab 500 dose calibrator and well counter system, and standard equipment for handling blood samples.