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Presentations |
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Research Interests
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As a student in the Medical Scientist Training Program (MSTP) I am interested in contributing to the understanding of the interplay between cells of the immune system and disease-causing agents, and how it ultimately affects clinical outcomes. During my undergraduate training at the University of Massachusetts Amherst, I examined the kinetic refolding properties of the metastable protein A1AT. After graduation, I spent two years at NIDDK at the NIH, seeking to elucidate, through application of genetic and biochemical techniques in Saccharomyces cerevisiae, the mechanisms by which prion formation is prevented and controlled. Specifically, I identified genetic relationships between a novel component of the yeast anti-prion system and other known and unknown actors previously found. |
| Publications |
Wickner, R.B., Edskes, H.K., Son, M., Wu, S., and Niznikiewicz, M. (2023). Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems. In Prions and Diseases (pp. 599-618). Cham: Springer International Publishing. Wickner, R.B., Edskes, H.K., Son, M., Wu, S., and Niznikiewicz M. (2021). Innate immunity to prions: anti-prion systems turn a tsunami of prions into a slow drip. Current Genetics, doi: 10.1007/s00294-021-01203-1. Epub ahead of print. PMID: 34319422. Wickner R.B., Edskes H.K., Son, M., Wu, S., and Niznikiewicz, M. (2020). How Do Yeast Cells Contend with Prions? International Journal of Molecular Sciences 21(13):4742. https://doi.org/10.3390/ijms21134742 |
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Honors and Awards |
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