Helene Benveniste, MD, PhD- Publications

Journal Articles

  • Benveniste H, Drejer J, Schousboe A, Diemer NH. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem, 1984 Nov;43(5):1369-1373. PMID: 6149259
  • Drejer J, Benveniste H, Diemer NH, Schousboe A. Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro. J Neurochem,1985 July;45(1):145-151. PMID: 2860206
  • Benveniste H, Drejer J, Schousboe A, Diemer NH. Regional cerebral glucose metabolism, blood flow and brain glucose content after insertion of a microdialysis fiber through the dorsal hippocampus in the rat. J Neurochem, 1987 Sep;49(3):729-734.  PMID: 3612121
  • Benveniste H, Diemer NH. Cellular reactions to implantation of a microdialysis tube in the rat hippocampus. Acta Neuropathol (Berl) 1987;74(3):234-238.  PMID: 3673515
  • Benveniste H, Diemer NH. Early postischemic 45Ca accumulation in rat dentate hilus.  J Cereb Blood Flow Metabol, 1988 Oct;8(5):713-719.  PMID: 3417798
  • Benveniste H, Jørgensen MB, Diemer NH, Hansen AJ. Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia. Acta Neurol Scand, 78;529-536. 1988.  PMID: 2906199
  • Benveniste H. Brain Microdialysis.  Short Review, J Neurochem, 52:1667-1679, 1989. PMID: 2656913
  • Benveniste H, Hansen AJ, Ottosen NS.  Determination of brain interstitial concentrations by microdialysis. J Neurochem, 52:1741-1750. 1989. PMID: 2723633
  • Benveniste H, Jørgensen MB, Christensen T, Sandberg M, Hagberg H, Diemer NH. Ischemia-induced damage in the hippocampal CA1 region depends on glutamate and intact innervation from CA3.  J Cereb Blood Flow Metabol. 1989 Oct; 9(5):629-639.  PMID: 2570785
  • Benveniste H, Hüttemeier P.  Microdialysis - Theory and application. Prog in Neurobiol, 1990; 35(3):195-215. PMID: 2236577
  • Maki JH. Benveniste H. MacFall JR. Johnson GA.  The maximization of contrast to noise in the separation of diffusion and microcirculatory flow.  J Magn Res Imag.  1991 Jan-Feb; 1(1):39-46.  PMID: 1802129
  • Benveniste H.  The excitotoxin hypothesis in relation to cerebral ischemia.  Cerebrovasc Brain Metab Rev.  1991 Fall;3(3):213-245.  PMID: 1931486
  • Benveniste H, Cofer GP, Dobbins JT III, Piantadosi CA, Davis JN, Johnson GA. Quantitative proton magnetic resonance imaging in focal cerebral ischemia. Stroke. 1991 Feb; 22(2):259-268.  PMID: 2003291
  • Hilgier W. Benveniste H. Diemer NH, Albrecht J.  Decreased glucose utilization in discrete brain regions of rat in thioacetamide-induced hepatic encephalopathy as measured with (3H)-deoxyglucose.  Acta Neurol Scand.  1991 June; 83(6):353-355.  PMID: 1887755
  • MacFall JR, Make JH, Johnson GA, Hedlund L, Benveniste H, Cofer G. Diffusion/Microcirculation MRI in the rat brain.  Magn Reson Med.  1991 June;19(2):305-310.  PMID: 1908936
  • Maki JH, Benveniste H, MacFall JR, Piantadosi CA, Johnson GJ.  MR imaging of microcirculation in rat brain: Correlation with carbon dioxide-induced changes in blood flow. J Magn Res Imag.  1991 Nov-Dec;1(6):673-681, 1991.  PMID: 1923172
  • Benveniste H, Hedlund LW, Johnson GA. Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy. Stroke.  1992 May;  23(5):746-754.  PMID: 1374575
  • Dobbins JT 3rd, Chotas HG, Benveniste H.  Direct digitization of optical images using a photostimulable phosphor system.  Med Phys.  1992 Jul-Aug;19(4):1071-1080.  PMID: 1518470
  • Diemer NH, Johansen FF, Benveniste H, Bruhn T, Berg M, Valente E, Jørgensen MB. Ischemia as an excitotoxic lesion: protection against hippocampal nerve cell loss by denervation. [Review]. Acta Neurochir Suppl (Wien).  1993; 57:94-101.  PMID: 8380675
  • Simonsen SG, Zhang J, Canada AT, Su Y-F, Benveniste H, Piantadosi CA. Hydrogen peroxide production by monoamine oxidase during ischemia-reperfusion in the rat brain.  J Cereb Blood Flow Metabol.  1993 Jan;13(1):125-134.  PMID: 8417001
  • Hüttemeier PC, Kamiyama Y, Su M, Watkins WD, Benveniste H.  Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1a in rat CA1 hippocampus during transient cerebral ischemia. Prostaglandins. 1993 Feb;45(2):177-187.  PMID: 8430228
  • Johnson GA, Benveniste H, Black RD, Hedlund LW, Maronpot RR, Smith BR.
  • Histology by magnetic resonance microscopy.  Magn Reson Q.  1993 Mar;9(1):1-30.  PMID:  8430228
  • Zhang J, Benveniste H, Piantadosi CA. Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia. Neurosci Lett.  1993 July 23;157(2):179-182.  PMID: 7694195
  • Hüttemeier PC, Ritter E, Benveniste H. Calcitonin-gene-related-peptide mediates hypotension and tachycardia in endotoxic rats.  Am J Physiol.  1993 Aug; 265(2 Pt 2):767-769.  PMID: 8368378
  • Zhang J, Benveniste H, Kiltzman B, Piantadosi CA. Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke. 1995 Feb;26(2):298-304.  PMID: 7530389
  • Hall LW, Benveniste H, Hedlund LW, Johnson GA.  A new in vivo method for quantitative analysis of stroke lesions using diffusion-weighted magnetic resonance microscopy. Neuroimage. 1196 June;3(3 Pt1):158-166.  PMID: 9345486
  • Johnson GA, Benveniste H, Engelhardt RT, Qui H, Hedlund LW. Magnetic resonance microscopy in basic studies of brain structure and function. Ann NY Acad of Sci.  1997 May 30;820: 139-147; discussion 147-148/Rev.  PMID: 9237453
  • Shiraishi M, Kamiyama, Y, Hüttemeier, PC, Benveniste H. Extracellular glutamate and dopamine measured by microdialysis in the rat striatum during blockade of synaptic transmission in anesthetized and awake rats. Brain Res.  1997 June 13; 759(2): 221-227.  PMID: 9221940
  • Qiu H, Hedlund LW, Gewalt SL, Benveniste H, Bare TM, Johnson GA. Progression of a focal ischemic lesion in rat brain during treatment with a novel Glycine/NMDA antagonist: an in vivo 3D diffusion-weighted MR microscopy study. J Magn Res Imag. 1997 Jul-Aug; 7(4):739-744.  PMID: 9243396
  • Scotland P, Zhou D, Benveniste H, Bennett V. Nervous system defects of ankyrin-B (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440 KD ankyrin-B in premyelinated axons. J Cell Biol.  1998 Nov 30;143(5):1305-1315.  PMID: 9832558.  PMCID: PMC2133070
  • Benveniste H, Qui H, Hedlund LW, D’Ercole F, Johnson GA. Spinal cord neural anatomy in rats examined by in vivo magnetic resonance microscopy.  Reg Anesth Pain Med.  1998 Nov-Dec; 23(6): 589-599.  PMID: 9840856
  • Klein SM, Benveniste H. Anxiety, vocalization, and agitation following peripheral nerve blockade with ropivacaine. Reg Anesth Pain Med.  1999 Mar-April:24(2):175-179.  PMID: 10204906
  • Benveniste H, Qui H, Hedlund LW, Hüttemeier PC, Steele SM, Johnson GA
  • In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: Effect of ischemia and intrathecal hyperbaric 5% lidocaine. Reg Anesth Pain Med, 1999 July-Aug; 24(4):311-318.  PMID: 10445769
  • Benveniste H, Einstein G, Kim K, Hulette C, Johnson GA. MR Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy. Proc Natl Acad Sci USA, 1999 Nov 23; 96(24):14079-14084.  PMID: 10570201, PMCID: PMC24193
  • Benveniste H, Kim KR, Hedlund LW, Kim JW, Friedman GA. Cerebral hemorrhage and edema following brain biopsy in rats: Significance of mean arterial blood pressure. J Neurosurg. 2000 Jan;92(1):100-107.  PMID: 1061088
  • Weissleder, R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca E A, Basilion J P. In vivo magnetic resonance imaging of transgene expression. Nat Medi. 2000 Mar;6(3): 351-354.  PMID: 10700241
  • Benveniste H, Kim KR, Zhang L, Johnson GA. Magnetic resonance microscopy of the C57BL mouse brain. Neuroimage 2000 June;11(6 Pt 1):601-1.  PMID: 10860789
  • McDaniel B, Sheng H, Warner DS, Hedlund LW, Benveniste H. Tracking brain volume changes in C57BL/6J and ApoE deficient mice in a model of neurodegeneration: a 5-week longitudinal microMRI study. Neuroimage. 2000 Dec;14(6):1244-55.  PMID: 11707081
  • Beck B, Plant DH, Grant SC, Thelwall PE, Silver X, Mareci TH, Benveniste H, Smith M, Collins C, Crozier S, Blackband, SJ. Progress in high field MRI at the University of Florida. MAGMA 2002 Jan; 13(3):152-7.  PMID: 11755090, PMCID: PMC3363288
  • Lynch J, Pineda J, Morgan D, Zhang, L, Warner D, Benveniste H, Laskowitz D, Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol 2002 Jan;51(1):113-7.  PMID: 11782990
  • Benveniste H, Blackband, SJ. MR microscopy and high resolution small animal MRI: applications in neuroscience research. Prog Neurobiol 2002 Aug;67(5):393-420.  PMID: 12234501
  • Benveniste H, Fowler, J. S., Rooney, W. D., Moller, DH, Backus WW, Warner DA, Carter P, King P, Scharf B, Alexoff DA, Ma Y, Vaska P, Schlyer D, Volkow ND. Maternal-fetal in vivo imaging: a combined PET and MRI study. J Nucl Med. 2003 Sept;44(9):1522-30.  PMID: 12960202
  • Benveniste H, Fowler JS, Rooney W, Ding YS, Baumann AL, Moller DH, Du C, Backus W, Logan J, Carter P, Coplan JD, Biegon A, Rosenblum L, Scharf B, Gatley JS, Volkow ND. Maternal and fetal 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primates. J Nucl Med. Feb 2005;46(2):312-20.  PMID: 15695792
  • Du C, Koretsky AP, Izrailtyan I, Benveniste H. Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using diffuse reflectance and fluorescence. J Cereb Blood Flow Metab. 2005 Aug;25(8):1078-92.  PMID: 15744244
  • Ding YS, Lin KS, Logan J, Benveniste H, Carter P. Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine. J Neurochem. 2005 Jul;94(2):337-51.  PMID: 15998285
  • Ma Y, Hof PR, Grant SC, Blackband SJ, Bennett R, Slatest L, McGuigan MD, Benveniste H. A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy. Neuroscience. 2005;135(4):1203-15.  Epub 2005 Sep 13.  PMID: 1615303
  • Adsumelli RS, Elimian A, Wiencek V, Benveniste HD, Glass PS, Quirk JG. Change in pulse pressure during the preclinical phase of preeclampsia. J Reprod Med 2006 Jan;51(1):26-30.  PMID: 16482773
  • Benveniste H, Blackband S. Translational neuroscience and magnetic-resonance microscopy. Lancet Neurol, 2006 June;5(6):536-43.  Rev. PMID: 16713925
  • Dilmanian, FA, Zong Z, Bacarian T, Romanelli P. Benveniste H, Wang R, Welwart J, Yuasa T, Rosen EM, Anschel D. Interlaced x-ray microplanar beams: a radiosurgery approach with clinical potential. Proc Natl Acad Sci USA. 2006 June 20;103(25):9709-14.  Epub 2006 June 7.  PMID: 16760251, PMCID: PMC1480471
  • Dow-Edwards DL, Benveniste H, Behnke M, Bandstra ES, Singer LT, Hurd YL, Stanford LR. Neuroimaging of prenatal drug exposure. Neurotoxicol Teratol. 2006 May-June;28(3): 386-402. PMID: 16832875
  • Du C, Yu M, Volkow N D, Koretsky A P, Fowler, J S, Benveniste H. Cocaine increases intracellular concentration of calcium in brain independent of its cerebrovascular effects. J Neurosci 2006 Nov;8;26(45):11522-31.  PMID: 17093073
  • Benveniste H, Ma Yu, Dhawan J, Gifford A, Smith SD, Feinstein I, Du C, Grant SC, Hof PR. Anatomical and functional phenotyping of mice models of Alzheimer’s disease by MR microscopy. Ann NY Acad Sci 2007 Feb;1097:12-29.  Rev. PMID: 17413006
  • Anschel DJ, Romanelli P, Benveniste H, Foerste B, Kalef-Ezra J, Zhong Z, Dilmanian FA. Evolution of a focal brain lesion produced by interlaced microplanar X-rays. Minim Invasive Neurosurg 2007 Feb;50(1):43-46.  PMID: 17546543
  • Thanos PK, Michaelides M, Benveniste H, Wang GJ, Volkow ND. Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents. Pharmcol Biochem Behav. 2007 Oct;87(4):426-33.  PMID: 17599397
  • Fowler JS, Kroll C, Ferrieri R, Alexoff D, Logan J, Dewey SL, Schiffer W, Schlyer D, Carter P, King P, Shea C, Xu Y, Muench L, Benveniste H, Vaska P, Volkow ND. PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and (--)cocaine. J Nucl Med. 2007 Oct;48(10):1724-32.  PMID: 17873134, PMCID: PMC2732342
  • Manganas L, Zhang X, Li Y, Hazel RD, Smith SD, Wagshul ME, Henn F, Benveniste H, Djuric PM, Enikolopov G, Maletic-Savatic M. Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science.  2007 Nov9;318(5852):980-5.  PMID: 17991865
  • Thanos PK, Michaelides M, Benveniste H, Wang GJ, Volkow ND. The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine transporter knockout mice. Synapse 2008 May;62(5):319-24.  PMID: 18286542, PMCID: PMC2681086
  • Volkow ND, Fowler JS, Wang GJ, Telang F, Logan J, Wong C, Ma J, Pradhan K, Benveniste H, Swanson JM. Methylphenidate decreased the amount of glucose needed by the brain to perform a cognitive task. PLoS ONE 2008 Apr 16;3(4):e2017.  PMID: 18414677, PMCID: PMC2291196
  • Baler RD, Volkow ND, Fowler JS, Benveniste H. Is fetal brain monoamine oxidase inhibition the missing link between maternal smoking and conduct disorders? J Psychiatry Neurosci. 2008 May;33(3):187-195.  PMID: 18592036, PMCID: PMC2441882
  • Ma Yu, Smith SD, Hof PR, Foerster B. Hamilton S, Blackband SJ, Benveniste H. In vivo 3D digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy. Front Neuroanat. 2008 April 17;2:1.  PMID: 18958199, PMCID: PMC2525925
  • Maletic-Savatic, M, Vingara, LK, Manganas, LN, Li Y, Zhang S, Sierra A, Hazel R, Smith SD, Wagshul ME, Henn F, Krupp L, Enikolopov G, Benveniste H, Djuric P, Pelczer I. Metabolomics of neural progenitor cells: A novel approach to biomarker discovery. Cold Spring Harb Symp Quant Biol. 2008;73:389-401.  Rev. PMID: 19022759
  • Luo Z, Yu M, Smith SD, Kritzer M, Du C, Ma Y, Volkow ND, Glass PS, Benveniste H. The effect of intravenous lidocaine on brain activation during non-noxious and acute noxious stimulation of the forepaw: a functional magnetic resonance imaging study in the rat. Anesth Analg 2009 Jan;108(1):334-44.  PMID: 19095870.  PMCID: PMC2681082
  • Benveniste H. Glutamate, microdialysis, and cerebral ischemia: lost in translation? Anesthesiology 2009 Feb;110(2):422-5.  PMID: 19194168
  • Connor DM, Benveniste H, Dilmanian FA, Kritzer MF, Miller LM, Zhong Z. Computed tomography of amyloid plaques in a mouse model of Alzheimer’s disease using diffraction enhanced imaging. Neuroimage 2009 Jul 15;46(4):908-14.  PMID: 19303447
  • Wagshul ME, McAllister JP, Rashid S, Li J, Egnor MR, Walker ML, Yu M, Smith SD, Zhang G, Chen JJ, Benveniste H. Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus. Exp Neurol. 2009 Jul;218(1):33-40.  PMID: 19348801
  • Du C, Tully M, Volkow ND, Schiffer WK, Yu M, Luo Z, Koretsky AP, Benveniste H. Differential effects of anesthetics on cocaine's pharmacokinetic and pharmacodynamic effects in brain. Eur J Neurosci. 2009 Oct;30(8):1565-75.  PMID: 19821842, PMCID: PMC2775450
  • Benveniste H, Fowler JS, Rooney WD, Scharf BA, Backus WW, Izrailtyan I, Knudsen GM, Hasselbalch SG, Volkow ND. Cocaine is pharmacologically active in the nonhuman primate fetal brain. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1582-7.  PMID: 20080687, PMCID: PMC2824386
  • Dhawan J, Benveniste H, Nawrocky M, Smith SD, Biegon A. Transient focal ischemia results in persistent and widespread neuroinflammation and loss of glutamate NMDA receptors. Neuroimage. 2010 Jun;51(2):599-605. PMID: 20206701, PMCID: PMC2856923
  • Glass P, Benveniste H. The adverse effects of volatile anesthetics: a conundrum. Anesth Analg. 2010 Jul;111(1):17-8. PMID: 20576963
  • Makaryus R, Lee H, Yu M, Zhang S, Smith SD, Rebecchi M, Glass PS, Benveniste H. The metabolomic profile during isoflurane anesthesia differs from propofol anesthesia in the live rodent brain. J Cereb Blood Flow Metab. 2011 June;31(6):1432-42. PMID: 21266982, PMCID: PMC3130322.
  • Delgado y Palacios R, Campo A, Henningsen K, Verhoye M, Poot D, Dijkstra J, Van Audekerke J, Benveniste H, Sijbers J, Wiborg O, Van der Linden A. Magnetic resonance imaging and spectroscopy reveal differential hippocampal changes in anhedonic and resilient subtypes of the chronic mild stress rat model. Biol Psychiatry. 2011 Sep 1;70(5):449-57. PMID: 21762877.
  • Delis F, Benveniste H, Xenos M, Grandy D, Wang GJ, Volkow ND, Thanos PK.  Loss of Dopamine D2 Receptors Induces Atrophy in the Temporal and Parietal Cortices and the Caudal Thalamus of Ethanol-Consuming Mice.  Alcohol Clin Exp Res. 2012 May;36(5):815-25. PMID: 22017419
  • Dhawan J, Benveniste H, Luo Z, Nawrocky M, Smith SD, Biegon A. A new look at glutamate and ischemia: NMDA agonist improves long-term functional outcome in a rat model of stroke. Future Neurol. 2011 Nov;6:823-834.  PMID: 22140354, PMCID: PMC3229223
  • Benveniste H, Zhang S, Reinsel R, Li H, Lee H, Rebecchi M, Moore W, Johansen C, Rothman DL, Bilfinger TV. Brain metabolomic profiles of lung cancer patients prior to treatment characterized by proton magnetic resonance spectroscopy.  Int J Clin Exp Med. 2012;5(2):154-164. PMID: 22567176, PMCID: PMC3342705.
  • Volkow ND, Tomasi D, Wang GJ, Telang F, Fowler JS, Logan J, Benveniste H, Kim R, Thanos PK, Ferré S. Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain. J Neurosci. 2012 May 9;32(19):6711-7. PMID:  22573693, PMCID: PMC3433285.
  • Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med. 2012 Aug 15;4(147):147ra111. PMID: 22896675, PMCID: PMC3551275.
  • Jacob Z, Li H, Makaryus R, Zhang S, Reinsel R, Lee H, Feng T, Rothman DL, Benveniste H. Metabolomic profiling of children's brains undergoing general anesthesia with sevoflurane and propofol. Anesthesiology. 2012 Nov;117(5):1062-71. PMID: 22929729.
  • Volkow ND, Kim S, Wang GJ, Alexoff D, Logan J, Muench L, Shea C, Telang F, Fowler JS, Wong C, Benveniste H, Tomasi D. Acute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brain. Neuroimage. 2013 Jan 1;64:277-83. PMID: 22947541.
  • Benveniste H, Volkow ND. Dopamine-enhancing medications to accelerate emergence from general anesthesia. Anesthesiology. 2013 Jan;118(1):5-6. PMID: 23208519.
  • Azim SA, Sangster R, Curcio C, Coleman D, Shah U, Zhang S, Reinsel R, Glass P, Nicholson J, Benveniste H. Characterization of patients with difficult-to-treat acute pain following total knee arthroplasty using multi-modal analgesia. Open Pain Journal. 2013, 6, 1-6.
  • Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, Benveniste H. Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. Journal of Clinical Investigation. 2013 Mar 1;123(3):1299-309. PMID: 23434588; PMCID: PMC3582150.
  • Durkin B, Romeiser J, Shroyer AL, Schiller R, Davis RP, Peyster R, Benveniste H. Report from a quality assurance program on patients undergoing the MILD procedure. Pain Med. 2013 May;14(5):650-6.  PMID: 23489390.
  • Yang L, Kress BT, Weber HJ, Thiyagarajan M, Wang B, Deane R, Benveniste H, Iliff JJ, Nedergaard M. Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer. J Transl Med. 2013 May 1;11(1):107. PMID: 23635358, PMCID: PMC3665671.
  • Lee H, Caparelli E, Li H, Mandal A, Smith SD, Zhang S, Bilfinger TV, Benveniste H. Computerized MRS voxel registration and partial volume effects in single voxel 1H-MRS. Magn Reson Imaging. 2013 May 6. [Epub ahead of print]. PMID: 23659770.
  • Szema AM, Hamidi SA, Smith SD, Benveniste H. VIP gene deletion in mice causes cardiomyopathy associated with upregulation of heart failure genes. PLoS One. 2013 May 20;8(5):e61449. PMID: 23700405; PMCID: PMC3659051.

BOOK CHAPTERS

  • Benveniste H, Hüttemeier PC, Johansen FF, Diemer NH. Calcium 45 accumulation in the dentate hilus:  Possible effect of NMDA receptor blockers.  In: Cerebral ischemia and calcium. Hartman A, Kuschinsky W eds, Springer-Verlag Berlin, Heidelberg, 266-273, 1989.
  • Benveniste H, Jørgensen MB, Lauritzen M, Lundbok JA, Zang E, Wieloch T, Hansen AJ.  The role of glutamate receptors for calcium entry in hippocampal neurons during ischemia.  In: Second international symposium on pharmacology of cerebral ischemia, Kuschinsky W, ed,  Wissensharfliche Verlagesellschaft,Stuttgart, 245-248, 1990.
  • Benveniste H, Hüttemeier PC, Diemer NH.  Differences in cellular origin of early and delayed postischemic 45-calcium accumulation.  In: Second international symposium on pharmacology of cerebral ischemia.  Wissen-shaftliche Verlagsgesellschaft, Stuttgart, 301-304, 1990.
  • MacFall JR, Maki JH, Johnson GA, Hedlund L, Benveniste H, Cofer GP. Diffusion/Microcirculation MRI with small animal models.  The society of Magnetic Resonance in Medicine.  Workshop: Future Direction in MRI of diffusion and microcirculation, 206-214, 1990.
  • Benveniste H, Hansen AJ.  Practical aspects of using microdialysis for determination of brain interstitial concentrations.  In: Sampling the neurohumoral environment with microdialysis.  Eds: Robinson TE, Justice JB Jr. eds, Elsevier, Holland, 36-45.
  • Benveniste H. Microdialysis - theory and application. In: Measuring the chemical microenvironment. Short course. Society for Neuroscience, 54-65, 1991.
  • Johnson GA, Benveniste H, Black RR, Cofer GP, Gewalt SL, Hedlund L, Maronpot RR, Suddarth S. MR Microscopy of disease models. In: Magnetic resonance microscopy.  Methods and applications in materials science, agriculture and biomedicine. Blümich B, Kuhn W, eds, VCH Verlagsgesellschaft, Weinheim, Federal Republic of Germany, 501-513, 1992.
  • Benveniste H, Johnson GA. Excitotoxicity and ischemia in the rat brain studied in vivo with high-resolution magnetic resonance imaging. Microcirculatory Stasis in the Brain, May 20-21, Tokyo, Japan.  Elsevier Press, 369-377, 1993.
  • Auer R, Benveniste, H: Hypoxia and related conditions. In: Greenfields Neuropathology. Eds: Graham DI and Lantos PL. Sixth edition. Arnold, London. 1997, 263-296.
  • Benveniste H, Warner D: The role of Glutamatergic neurotransmission in ischemic brain damage. In: Cerebrovascular Disease: Pathology, Diagnosis and Management. Eds: Ginsberg M, Bogousslavsky J. Vol 1: 393-402, 1998.
  • Benveniste H. MR Microscopy of Mouse Brain. In Vivo Microscopy: Technologies and Applications. NIH NCCR workshop. March 18-19, Gaithersburg Washingtonian Center, MD. 1999.
  • Benveniste H, Mareci T, Blackband SJ. Anatomical Studies in the Rodent Brain and Spinal Cord: Applications of Magnetic Resonance Microscopy. In: Biomedical Imaging in Experimental Neuroscience. Eds. Van Bruggen N, Roberts, T. CRC Press. pp. 211-235, 2003.
  • Smith, SD, Ma Y, Said SI, Benveniste H. MR Microscopy of the Rodent brain. In: Molecular Imaging of the Rodent Brain; Neuromethods Series; Bacskai BJ, Ed. Human Press. In Press 2008.
  • Benveniste H, Zeqo J. Overhextending yourself. In: Core Clinical Competencies in Anesthesiology: A Case-Based Approach. Cambridge University Press, 2010.

Scientific Abstracts (from 2000)

  • Pineda J, Lynch J, Laskowitz D, Warner D, Benveniste H. High resolution MRI of closed head injury in 30-g transgenic mice. Society for Neuroscience 30thannual mtg. 2000.
  • Du C., Izrailtyan I., Benveniste H., "Fluorescence and optical detection of brain activation in vivo ", DOE Workshop on Neuroimaging. Oct. 27-29, Massachusetts, 2003.
  • Du C., MacGowan G. A., Benveniste H., Koretsky A. P., " Optical optimization in calcium transient detection from intact mouse heart ", Accepted by Biomedical Engineering Society Annual Meeting for oral presentation, Oct. 1-4, Tennessee, 2003.
  • Benveniste H, Fowler JS, Rooney WD, Moller DH, Backus WW, Warner DA, Carter P, King P, Scharf B, Alexoff DA, MA Y, Vaska P, Schlyer D, Volkow ND.  Maternal-fetal in vivo imaging: a combined PET and MRI study.  In: Proceedings Society of Nuclear Medicine 50th Annual Meeting. New Orleans, LA, June 21-25, 2003.
  • Wolf A., Du C., Benveniste H.,  " Imaging rat brain function using calcium-sensitive fluorescent dye Rhod2 ", Biomedical Engineering Society Annual Meeting, (oral presentation), 2004.
  • Du C., Izrailtyan I., Benveniste H., "A new fluorometric and optical technological approach for tracking of intracellular calcium, blood volume and oxygenation changes in the rat brain in vivo", Optical Society America Biomedical Topical Meeting (oral presentation), April. 14-17, Florida, 2004.
  • Du C., Izrailtyan I., Benveniste H., "Optical and fluorescent imaging in vivo at BNL ", NIBIB-DOE Workshop on Biomedical Imaging: Optical and X-ray Technologies, Feb. 10-11, Maryland, 2004.
  • Izrailtyan I, Fowler J, Glass PSA, Rampil IJ, Bicker AA, Baumann A, Feinstein I, Scharf B, Siram A, Benveniste HD.  Bispectral  index (BIS) monitoring during maternal-fetal brain imaging in a non-human primate model.  In: Proceedings of the Association of University Anesthesiologists 51st Annual Meeting.  Sacramento, CA, May 13-15, 2004.
  • Benveniste H, Fowler JS, Rooney W, Ding Y-S, Baumann A, Vaska P, Logan J, Gatley SJ.  Maternal and fetal brain [11C] cocaine uptake measured in vivo. In: Proceedings Society of Nuclear Medicine 51th Annual Meeting.  Philadelphia, PA, June 19-23, 2004.
  • Du C.,  Koretsky A. P., Benveniste H.,  " Simultaneous measurement of blood volume, oxygenation and intracellular calcium in the rat brain in vivo ", Gordon Research Conference on Brain Energy Metabolism and Blood Flow, August 8-13, Waterville, Maine, 2004.
  • Wolf A., Du C., Pan Y., Benveniste, H. Microscopic Imaging of Calcium After Ischemia Using Calcium-Sensitive Fluorescent Dye Rhod2. Biomedical Engineering Society Annual Fall Meeting, Oct 13-16, 2004 Philadelphia.
  • J. Bentwich, H. Benveniste, D. A. Ziegler, M. Maletic-Savatic, P. A. Filipek, D. Kennedy, N. Makris, V. S. Caviness, M.R. Herbert. Rightward Volumetric Asymmetry in Mentalizing Networks in Autistic Cerebral Cortex International Meeting for Autism Research (IMFAR). UC Davis, May 5-7, 2005.
  • Identification of Neural Stem Cells by Magnetic Resonance Spectroscopy. Louis Manganas, William Rooney, Grigori Enikolopov, Petar Djuric, Helene Benveniste and Mirjana Maletic-Savatic. Key Stone Symposium on stem cells. February, 2005.
  • 9.4T MRI Characterization of a Focal Lesion in the Rat Brain Induced by Interlaced Microbeam Radiation”, Anshel, D, Benveniste H, Romanelli P, Zong Z, Welwart J, Becarian T, Rosen E, Dilmanian A. American Epilepsy Society and American Clinical Neurophysiology Society Joint Annual Meeting, October, 2005.
  • Du, C., Ma Y, Forester B., Yu M., Benveniste H. “The effect of cocaine on the rat brain apparent diffusion coefficient, cerebral blood volume and mean arterial blood pressure”, 14th International Society for Magnetic Resonance in Medicine, Seattle (2006).
  • Y. Ma, PR. Hof, SC. Grant, SJ. Blackband  S. Rubinstein and H. Benveniste.Magnetic Resonance Microscopy of a Mouse Model of Attention-Deficit-Hyperactivity Disorder: Role of D4 dopamine receptors. 14th International Society for Magnetic Resonance in Medicine, Seattle (2006).
  • Izrailtyan I, Smith SD, Morris R, Hojer S, Feinstein I, Glass PSA, Benveniste H. Cardiac magnetic resonance enabled pressure-volume relationship analysis in the rodent. Association of University Anesthesiologists, Tucson, Arizona. 2006.
  • Measurement of cerebrospinal fluid flow in the aqueduct of a rat model of hydrocephalus. Hazel, McCormack, Miller, Li, Yu, Benveniste H, McAllister, Egnor, Wagshul. 14th International Society for Magnetic Resonance in Medicine, Seattle (2006).
  • Identification of neural stem cells in rat brain using their specific magnetic resonance spectroscopy signature. Hazel, Manganas, Zhang, Yu, Djuric, Benveniste H, Wagshul, Maletic-Savatic. 14th International Society for Magnetic Resonance in Medicine Seattle, (2006).
  • ‘More’ may be ‘less’: Deficient dichotic listening performance in autism is associated with hyperactivation of bilateral language brain regions. Bentwich J, Maletic-Savatic M, Caparelli C, Anshul A, Foerster B, Cohen M, Pradhan K, Ma Y, Benveniste, H 14th International Society for Magnetic Resonance in Medicine Seattle, (2006).
  • Direct Measurement of Intra Ventricular and Atrial Pressures Concurrent with MR Image Acquisition. Smith SD, Benveniste H, Morris GR, Hojer S, Izrailtyan I, Yu M, Du C, Luo Z, Ma Y, Lee H-D, Feinstein I. 14th International Society for Magnetic Resonance in Medicine Seattle, (2006).
  • Du C., Z.C. Luo, M. Yu, H. Benveniste, “Optical approach to detect vascular functional changes induced by cocaine in living rat brain”, Accepted forProceeding of Biomedical Optics conference, Optical Society of America (OSA), 2006.
  • Du C., Wolf A., Perez Y., Pan Y.T., Benveniste H, “Microscopic Fluorescence Studies on Brain Intracellular Ca2+ Responses to Ischemia with and without Ca2+- Channel Blockade”, Proceeding of Biomedical Optics conference, Optical Society of America (OSA), 2006.
  • Z. C. Luo, J Dhawan, H Benveniste, M Yu, A Gifford, C Du, “Local cerebral blood flow responses to direct stimulation in somatosensory cortex: Laser doppler flowmetric and autoradiographic analysis” , Proceeding of Biomedical Optics conference, Optical Society of America (OSA), 2006.
  • Du, C., Ma Y, Forester B., Yu M., Benveniste H “The effect of cocaine on the rat brain apparent diffusion coefficient, cerebral blood volume and mean arterial blood pressure”, Accepted for International Society for Magnetic Resonance in Medicine , (2006).
  • Luo Z et al., Combining Laser Doppler Speckle Contrast Imaging and Optical Coherence Tomography for Quantitative Imaging of Cortical Blood Flow in Rat Brain' . Optical Society of America Biomedical Optics Topical Meeting (BIOMED), Florida, Mar 16-19. 2008.
  • Du C, Luo Z, Yu M, Benveniste H. Detection of Ca2+-Dependent Neuronal Activity Simultaneously with Dynamic Changes in Cerebral Blood Flow, Blood Volume and Oxygenation in Somatosensory Cortex of the Live Rat Brain. 2008 Biomedical Optics Topical Meeting (BIOMED). BIOMED will be held March 16-19, 2008 at the Hilton St. Petersburg Bayfront in St. Petersburg, Florida, USA.
  • Smith SD, Szema A, Said SI, Benveniste H. Functional Cardiac Phenotyping of Vasoactive Intestinal Peptide (VIP) deficient mice by MR Microscopy. ISMRM 2008 Annual Meeting in Toronto, Ontario, Canada.
  • Luo Z, Yu M, Smith SD, Kritzer M, Ma Y, Du C, Volkow ND, Glass PS, Benveniste H. Effect of intravenous lidocaine on brain activation during non-noxious and acute noxious stimulation of the forepaw: A functional MRI study in the rat. ISMRM 2008 Annual Meeting in Toronto, Ontario, Canada.
  • Luo Z, Yu M, Smith SD, Kritzer M, Ma Y, Du C, Volkow ND, Glass PS, Benveniste H. Systemic lidocaine does not block the brain’s response to noxious stimuli. Association of University Anesthesiologists. Duke University, Durham NC, May, 2008.
  • Feinstein I, Kritzer M, Djuric P, Li Y, Smith SD, Benveniste H. Adapting Proton MRS for non-invasively measuring amine neurotransmitters and their major metabolites in vitro. ISMRM 2008 Annual Meeting in Toronto, Ontario, Canada.
  • Du C, Tully M, Yu M, Glass PA, Benveniste H. Anesthetics Modify Cocaine’s Pharmaco-dynamic Responses in the Live Brain. Association of University Anesthesiologists 2009 Annual Meeting, Galveston, Texas.
  • Makaryus R, Yu M, Smith SD, Rampil I, Rebecchi M, Zhang S, Benveniste H. The brain metabolomic profile during isoflurane anesthesia differs from propofol anesthesia: implications for agent-specific neurotoxicity. Association of University Anesthesiologists 2010 Annual Meeting, Denver, Colorado.
  • Benveniste H, Fowler JS, Rooney WD, Scharf BA, Backus WW, Izrailtyan I, Knudsen GM, Hasselbalch SG, Volkow ND. Cocaine is Pharmacologically active in the non-human primate brain. International Anesthesia Research Society 2010 Annual Meeting, Honolulu, Hawaii.
  • Makaryus R, Smith SD, Lee H, Zhang S, Benveniste H. Isoflurane Increases Lactate Levels in the Rat Brain in a Dose Dependent Fashion. American Society of Anesthesiologists 2010 Annual Meeting, San Diego, California.
  • Jacob Z, Li H, Zhang S, Jambawalikar S, Reinsel R, Benveniste H. The Concentration of Brain Lactate Can Predict Anesthesia Emergence Delirium in Children Anesthetized with Sevoflurane. Association of University Anesthesiologists 2011 Annual Meeting, Philadelphia, Pennsylvania.
  • Azim SA, Sangster R, Coleman D, Curcio C, Reinsel RA, Benveniste H. Post-operative pain following knee arthroplasty: Role of age, gender and obesity. International Anesthesia Research Society 2011 Annual Meeting, Vancouver, British Columbia, Canada.
  • Liu T, Durkin B, Benveniste H, Biel C. Patient-Reported Outcomes Measurement Information System (PROMIS) assessment in lumbar spinal stenosis (LSS) patients undergoing minimally invasive lumbar decompression (MILD). American Society of Anesthesiologists 2011 Annual Meeting, Chicago, Illinois.
  • Durkin B, Besleaga D, Gyi J, Benveniste H. Delayed Outcome Improvement At 6 Weeks Following Percutaneous Decompression And Laminotomy At L2-3 And L4-5 Using The Mild Technique. New York State Society of Anesthesiologists Post-Graduate Assembly 2011 Annual Meeting, New York City, New York.
  • Durkin B, Romeiser J, Peyster R, Shroyer ALW, Davis R, Benveniste H. Pain, Functional and Mood Status in Patients with Neurogenic Claudication before and after Minimally Invasive Lumbar Decompression. International Anesthesia Research Society 2012 Annual Meeting, Boston, Massachusetts.
  • Makaryus R, Lee H, Jacob Z, Yu M, Feng T, Benveniste H. Metabolic Status in Neonatal Rat Brain in Response to General Anesthesia Differs from the Young Rat Brain: The Role of Glutamate. International Anesthesia Research Society 2012 Annual Meeting, Boston, Massachusetts and Association of University Anesthesiologists 2012 Annual Meeting, Atlanta, Georgia.
  • Azim S, Nicholson J, Reinsel R, Rebecchi M, Benveniste H. Subclinical systemic inflammation in obese patients prior to total knee arthroplasty (TKA). Association of University Anesthesiologists 2012 Annual Meeting, Atlanta, Georgia.
  • Jacob Z,Li H, Jambawalikar S, Makaryus R, Zhang S, Reinsel R, Lee H, Rothman D, Benveniste H. The concentration of brain lactate can predict anesthesia emergence delirium in children. International Anesthesia Research Society 2012 Annual Meeting, Boston, Massachusetts.
  • Lee H, Zhang S, Yu M, Makaryus R, Smith D, Volkow N, Benveniste H. Methylphenidate's Effects on the Metabolomic Profile of the Rat Brain measured by 1H-MRS. ISMRM 2012 Annual Meeting in Melbourne, Australia.
  • Lee H, Zvi J, Li H, Reinsel R, Zhang S, Benveniste H. Age related morphometric and metabolic changes in pediatric brains. ISMRM 2012 Annual Meeting in Melbourne, Australia.
  • Lee H, Caparelli E, Li H, Reinsel R, Mandal A, Smith D, Zhang S, Benveniste H. Automated partial volume calculation in single voxel 1H-MRS. ISMRM 2012 Annual Meeting in Melbourne, Australia.
  • Durkin B, Schiller R, Romeiser JL, Shroyer AL, Peyster R, Hwang F, Davis R, Hildebrand S, Benveniste H. A Prospective Quality Initiative Outcome Study of the Minimally Invasive Lumbar Decompression Procedure. American Society of Interventional Pain Physicians 2012 Annual Meeting, Washington, DC.
  • Ernst M, Durkin B, Benveniste H. Effect of Preoperative Mental Health Status on Outcomes Following Minimally Invasive Lumbar Decompression. American Society of Anesthesiologists 2012 Annual Meeting, Washington, DC.