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Guangming Chen, PhD
Postdoctoral Associate Email: guangming.chen@stonybrookmedicine.edu |
Dr. Chen received his Bachelor’s degree in Pharmacy from Shandong University in 1997, his Master’s degree in Microbiological Pharmaceutics from China Pharmaceutical University in 2003 and his PhD degree in Pharmacology from Chinese Academy of Science in 2011. His research areas focus on cancer molecular biology and cancer therapy, including the mechanism of tumor happening and development, cancer targeting therapy and drug resistance. He also has rich experience on recombinant protein preparation.
Dr. Chen’s current projects are on ovarian and lung cancer treatments using novel compounds and their molecular biology mechanism.
Selected Publications
- Xuan Gao; Guangming Chen; Chenxi Gao; Shih-Fan Kuan; Laura Stablile; Guoxiang Liu; Jing Hu. MAP4K4 is required for the malignant phenotype of lung adenocarcinoma by promoting MAPK/ERK signaling. Molecular Oncology. (Accepted)
- Chenxi Gao*, Guangming Chen*, Shih-Fan Kuan, Dennis Han Zhang, David D Schlaepfer, Jing Hu. FAK/PYK2 Promotes the Wnt/B-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β. eLife. 2015;4:e10072 (*Contribute equally)
- Chenxi Gao, Guangming Chen, Guillermo Romero, Stergios Moschos, Xiang Xu, Jing Hu. Induction of Gsk3β-β-TrCP Interaction Is Required for Late Phase Stabilization of β-catenin in Canonical Wnt Signaling. JBC. 2014;289:7099-108.
- Guangming Chen, Liang Da, Hongfei Wang, Ying Xu, Guoyuan Chen, Chengfu Sun, Leiming Wang, Jing Zhao, Fang Zhang, Jian Feng, Yifei Wang, Pierre Tiollais, Tsaiping Li, Mujun Zhao. HIV-Tat-mediated delivery of an LPTS functional fragment inhibits telomerase activity and tumorigenicity of hepatoma cells. Gastroenterology. 2011;140:332-43
- Guangming Chen, Changlin Zhou, Yuangang Wei, Minglong Zhao. Purification of Recombinant Human Serum Albumin from Fermentation Broth. Pharmaceutical Biotechnology. 2003;10(1):25-8
For a complete list of publications, Click Here.
