James P. Dilger, PhD | Renaissance School of Medicine at Stony Brook University

Education

1974-79 Stony Brook University. Ph.D. Physics/Biophysics
1980-82 University of Cambridge, Cambridge, UK. Postdoc in Physiology
1982-84 Stony Brook University. Postdoc in Neurobiology

Research Interests

Mechanisms of anesthetic action
Ligand gated ion channel kinetics
TRPM7 channels
Role of ion channels in cancer
Nicotinic receptors in cnidarians

Awards, Honors, Professional Appointments

Adjunct Professor of Physiology and Biophysics
2007-2011. NIH Study Section: Surgery, Anesthesiology and Trauma
2001-present. Judge at Long Island Science and Engineering Fair (LISEF)
2015-present. Judge at New York State Science and Engineering Fair (NYSSEF)

PubMed Search
https://orcid.org/0000-0002-8928-3283
Wenningmann I, Dilger JP. Die Kinetik der Inhibition nichtdepolarisierender Muskelrelaxantien am nikotinergen Acetylcholinrezeptor. Anasthesiol Intensivmed Notfallmed Schmerzther. 35:607-608, 2000
Barann M, Dilger JP, Bönisch H, Göthert M, Dybek A, Urban BW. Inhibition of 5-HT3 receptors by propofol: Equilibrium and kinetic measurements. Neuropharmacology. 39:1064-1074, 2000.
Eger EI, Fisher DM, Dilger JP, Sonner JM, Evers A, Franks NP, Harris RA, Kendig JJ, Leib WR, Yamakura T. Relevant concentrations of inhaled anesthetics for in vitro studies of anesthetic mechanisms. Anesthesiology 94:915-921, 2001.
Spitzmaul G, Dilger JP, Bouzat C. The noncompetitive inhibitor quinacrine modifies the desensitization kinetics of muscle acetylcholine receptors. Mol Pharmacol 60:235-243, 2001.
Wenningmann I, Barann M, Vidal AM, Dilger JP. The effects of isoflurane on acetylcholine receptor channels: 3. Effects of conservative polar-to-nonpolar mutations within the channel pore. Mol Pharmacol 60:584-594, 2001.
Wenningmann I, Dilger JP. The kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and pancuronium. Mol Pharmacol 60:790-796, 2001.
Demazumder D, Dilger JP. The kinetics of competitive antagonism by cis-atracurium of embryonic and adult nicotinic acetylcholine receptors.Mol Pharmacol. 60:797-807, 2001.
Dilger JP. The effects of general anaesthetics on ligand-gated ion channels. Br. J. Anaesth. 2002 89: 41-51.
Friederich P, Dilger JP, Isbrandt D, Sauter K, Pongs O, Urban BW. Biophysical properties of Kv3.1 channels in SH-SY5Y human neuroblastoma cells. Receptors Channels. 2003;9(6):387-96.
Saunders T, Dilger JP, Stein D. Informed consent for labor epidurals: A survey of SOAP anesthesiologists. Int J Obstet Anesth. 2006 Apr;15(2):98-103
Dilger JP, Vidal AM, Liu M, Mettewie C, Suzuki T, Pham A, Demazumder D. Roles of amino acids and subunits in determining the inhibition of nicotinic acetylcholine receptors by competitive antagonists Anesthesiology. 2007 Jun;106(6):1186-1195
Liu M, Dilger JP. Synergy between Pairs of Competitive Antagonists at Adult Human Muscle Acetylcholine Receptors . Anesth Analg 2008 Aug;107(2):525-33
Demazumder D, Dilger JP. The kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperature. J Physiol 2008 586:951-63
Spitzmaul G, Gumilar F, Dilger JP, Bouzat C. The Local Anesthetics Proadifen and Adiphenine Inhibit Nicotinic Receptors by Different Molecular Mechanisms. Br J Pharmacol. 2009 Jul;157(5):804-17. Epub 2009 Apr 30
Liu M, Dilger JP. Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor. Mol Pharmacol. 2009 Jan;75(1):166-73. Epub 2008 Oct 8
Dilger JP. Monte Carlo simulation of buffered diffusion into and out of a model synapse. Biophys J. 2010 Mar 17;98(6):959-967
Dilger JP. Simulation of the kinetics of neuromuscular block: Implications for speed of onset. Anesth Analg. 2013 Oct;117(4):792-802.
Muller J, Pentyala S, Dilger J, Pentyala S. Ketamine enantiomers in the rapid and sustained antidepressant effects. Ther Adv Psychopharmacol. 2016 Mar 10;6(2):1-8
Leng T, Gao X, Dilger JP, Lin J. Neuroprotective effect of lidocaine: is there clinical potential? Int J Physiol Pathophysiol Pharmacol. 2016 Apr 25;8(1):9-13
Pentyala S, Dilger JP, Rebecchi M. Minority Students and STEM Careers: Will Mentoring Help? J Health Edu Res Dev 2016 4: 175
Maloney LM, Dilger J, Werfel PA, Cimino LM. Are Audience Response Systems Worth the Cost? Comparing Question-Driven Teaching Strategies for Emergency Medical Technician Education. The Internet Journal of Allied Health Sciences and Practice. 2017 Dec 22;16(1), Article 8
Ma L, Dilger JP. Antimicrobial Peptides as Potential Therapy for Gastrointestinal Cancers: Opportunities and Challenges. in: Antimicrobial Peptides in Gastrointestinal Diseases. 2018. Cho CH, ed. Elsevier Ltd
Li R, Xiao C, Liu H, Huang Y, Dilger JP, Lin J. Effects of local anesthetics on breast cancer cell viability and migration. BMC Cancer. 2018 Jun 19;18(1):666.
Li R, Liu H, Dilger JP, Lin J. Effect of propofol on breast cancer cell, the immune system, and patient outcome. BMC Anesthesiol. 2018 Jun 26;18(1):77.
Goswami LN, Olds TJ, Monk TG, Johnson QL, Dilger JP, Shanawaz MA, Jalisatgi SS, Hawthorne MF, Kracke GR. Isomeric Carborane Neuromuscular Blocking Agents. ChemMedChem. 2019 Mar 21
Liu H, Dilger JP, Lin J The Role of Transient Receptor Potential Melastatin 7 (TRPM7) in Cell Viability: A Potential Target to Suppress Breast Cancer Cell Cycle. Cancers (Basel). 2020 Jan 4;12(1)
Liu H, Dilger JP, Lin J. Effects of local anesthetics on cancer cells. Pharmacol Ther. 2020 Apr 25:107558.
Liu H, Dilger JP, Lin J. Lidocaine Suppresses Viability and Migration of Human Breast Cancer Cells: TRPM7 as A Target for Some Breast Cancer Cell Lines. Cancers (Basel). 2021 Jan 10;13(2):E234.
Figueiredo J, Rest J, Adamo S, Grella R, Dilger JP. Nicotine Stimulates Peristalsis in N. Vectensis: From Behavior to Nicotinic Receptor Genes. 16 February 2021, PREPRINT (Version 1) available at Research Square.
Liu H, Dilger JP, Lin J. A pan-cancer-bioinformatic-based literature review of TRPM7 in cancers. Pharmacol Ther. 2022 Nov 1:108302
Li R, Mukherjee MB, Jin Z, Liu H, Lin K, Liu Q, Dilger JP, Lin J. The Potential Effect of General Anesthetics in Cancer Surgery: Meta-Analysis of Postoperative Metastasis and Inflammatory Cytokines. Cancers (Basel). 2023 May 15.
Dilger, JP. Wordle: A Microcosm of Life. Luck, Skill, Cheating, Loyalty, and Influence! September 2023, PREPRINT (version 2).
Li R, Huang Y, Lin K, Li X, Dilger JP, Lin J. Distinct effects of sevoflurane and propofol on vascular permeability in vitro and in a mouse model. Anesthesiology. 2025 Mar 5

S.G. McLaughlin, M. Eisenberg, F. Cohen, Dilger JP. The unique ability of picrate to uncouple submitochondrial particles but not mitochondria is consistent with the chemiosmotic hypothesis. In: Frontiers of Biological Energetics, Vol. 2. Ed. Dutton, Leigh and Scarpa, Academic Press, NY, 1978, pp.1205-1213.
J. Kirz, D. Sayre, Dilger JP. Specimen damage considerations in choosing the probe for the microanalysis of thin biological materials. In: Proceedings of the VIIIth International Congress on x-ray Optics and Microanalysis. Ed. Beaman, Ogilvie and Wittry. Pendell Pub. Co. Midland, MI, 1980, pp.494-496.
T. McIntosh, S. Simon, Dilger JP. Location of the water-hydrocarbon interface in lipid bilayers. In: Water transport in biological membranes: Volume I. From model membranes to isolated cells. G. Benga, editor. CRC Press. 1989.
Dilger JP, J. Santos-Sacchi. Patch clamp recording from hair cells. In: Physiology of the Ear. A.F. Jahn and J.R. Santos-Sacchi (eds.) Raven Press, New York. 1988. pp 487-496.
Dilger JP. Basic pharmacology of inhalational anesthetics. In: The pharmacological basis of anesthesiology: Basic science and clinical applications. T.A. Bowdle, A. Horita and E.D. Kharasch (eds.) Churchill Livingstone. 1994. pp. 497-521.
Dilger JP. Structure and function of the nicotinic acetylcholine receptor. In: Anesthesia: Biological Foundations. J.F. Biebuyck, C. Lynch, M. Maze, L.J. Saidman, T.L. Yaksh and W.M. Zapol (eds.) Raven Press 1997. pp. 221-237.
Dilger JP. Basic pharmacology of volatile anesthetics. In: Molecular Bases of Anesthetics. P. Skolnick and E.J. Moody (eds.) CRC Press 2001, Boca Raton, FL, pp. 1-35
I. Wenningmann, D. Demazumder and Dilger JP. Kinetics of inhibition of nicotinic ACh receptors by metocurine. In: Molecular and Basic Mechanisms of Anesthesia. Pabst Science Publishers 2002, Germany pp. 120-4
Dilger JP, D. Oustecky, and C.J. Tzan. Kinetics Count! Examples using the acetylcholine receptor. In: Molecular and Basic Mechanisms of Anesthesia. Pabst Science Publishers 2002, Germany pp. 52-7
Dilger JP. Whence cometh the steepness of MAC? In: Molecular and Basic Mechanisms of Anesthesia. Pabst Science Publishers 2002, Germany pp. 558
L. Ma, Dilger JP. Antimicrobial Peptides as Potential Therapy for Gastrointestinal Cancers: Opportunities and Challenges. In: Antimicrobial Peptides in Gastrointestinal Diseases. Cho CH, ed. Elsevier, 2018.

Dilger JP, Jin Z, Lin J, Liu H. Effects of Lidocaine on Breast Cancer Cells and the Potential Role of Transient Receptor Potential Melastatin 7 (TRPM 7). International Anesthesia Research Society Meeting, May 2019.
Shanawaz M, Dilger JP. When a gain becomes a loss: Gain-of-function glycine receptors and hyperekplexia. Biophysical Society Meeting, February 2021
Lin J, Li R, Huang Y, Dilger JP, Mukherjee MB. Increased lung metastasis with sevoflurane in breast cancer surgery is associated with VEGF and elevated vascular permeability by VEGF in a mouse model of human breast cancer. Journal of Clinical Oncology 2022: 40 (16_suppl), e13060-e13060