Srinivas N. Pentyala Research

Research interests are to bridge the gap between basic and clinical research. Projects to develop diagnostic tests for detecting cerebrospinal fluid leaks and prostate cancer are in progress. A bioinformatics project on lead drug discovery using specific algorithms to identify bioactive peptides is also in progress.

Basic research projects involve molecular actions of intravenous and inhalational anesthetics with regard to their effect on signal transduction pathways. Particularly, the effect of intravenous drugs on calcium flux and the effect of inhalational drugs on G-protein signaling mechanisms are being studied. Signaling mechanisms involving calcium-mobilizing enzymes in relation to cancer and cell death are also being studied.