Sergio D. Bergese, MD, CBA, FASA

Professor of Anesthesiology and Neurological Surgery
Vice Chair for Professional Development
Director of Outcomes and Clinical Research in Perioperative Medicine
Phone: 631-444-2975
Stony Brook Medicine Profile
  • Education  
  • National University of Cordoba, Argentina - MD
  • Residency: Italian Hospital of Cordoba, Surgery
  • Residency: Ohio State University Hospital, Anesthesiology
  • Residency: Ohio State University Hospital, Surgery
  • Research Fellowship: Ohio State University Medical Center, Transplantation
  • Awards, Honors, Professional Appointments   
  • ASA/SEA Distinguished Educator in Anesthesiology Award, 2019
  • Recent Publications   
  • PubMed Search
  • Stoicea N, Costa A, Periel L, Uribe A, Weaver T, Bergese SD. Current perspectives on the opioid crisis in the US healthcare system: A comprehensive literature review. Medicine (Baltimore). 2019 May;98(20):e15425
  • Candiotti KA, Kranke P, Bergese SD, Melson TI, Motsch J, Siddiqui N, Chung F, Rodriguez Y, Minkowitz HS, Ayad SS, Diemunsch P, Fox G. Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Amisulpride as Treatment of Established Postoperative Nausea and Vomiting in Patients Who Have Had No Prior Prophylaxis. Anesth Analg. 2019 Jun;128(6):1098-1105
  • Jones LM, Uribe AA, Coffey R, Puente EG, Abdel-Rasoul M, Murphy CV, Bergese SD. Pregabalin in the reduction of pain and opioid consumption after burn injuries: A preliminary, randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019 May;98(18):e15343
  • Viscusi ER, Gan TJ, Bergese S, Singla N, Mack RJ, McCallum SW, Du W, Hobson S. Intravenous meloxicam for the treatment of moderate to severe acute pain: a pooled analysis of safety and opioid-reducing effects. Reg Anesth Pain Med. 2019 Feb 7.
  • Awad H, Ahmed A, Urman RD, Stoicea N, Bergese SD. Potential role of pharmacogenomics testing in the setting of enhanced recovery pathways after surgery. Pharmgenomics Pers Med. 2019 Jul 26;12:145-154.
  • Dada O, Gonzalez-Zacarias A, Echeverria-Villalobos M, Bergese SD, Moran K. Does Rebound Pain after Peripheral Nerve Block for Orthopedic Surgery Impact Postoperative Analgesia and Opioid Consumption? A Narrative Review. Int. J. Environ. Res. Public Health 2019, 16(18), 3257.
  • Bergese SD, Brzezinski M, Hammer GB, Beard TL, Pan PH, Mace SE, Berkowitz RD, Cochrane K, Wase L, Minkowitz HS, Habib AS. ATHENA: A Phase 3, Open-Label Study of the Safety and Effectiveness of Oliceridine (TRV130), a G-Protein Selective Agonist at the μ-Opioid Receptor, in Patients with Moderate to Severe Acute Pain Requiring Parenteral Opioid Therapy. Journal of Pain Research 2019:12 3113–3126.
  • Awad H, Bai M, Ramadan ME, Shabsigh A, Backes F, Craven MA, Abdel-Rasoul M, Bergese SD, Slabaugh M. The Effect of Increased Intraocular Pressure During Steep Trendelenburg Positioning in Robotic Prostatectomy and Hysterectomy on Structural and Functional Ocular Parameters. Anesth Analg. 2019 Dec 9.
  • Borrell-Vega J, Uribe AA, Palettas M, Bergese SD. Clevidipine use after first-line treatment failure for perioperative hypertension in neurosurgical patients: A single-center experience. Medicine (Baltimore). 2020 Jan;99(1):e18541.
  • Uribe AA, Stoicea N, Echeverria-Villalobos M, Todeschini AB, Esparza-Gutierrez A, Folea AR, Bergese SD. Postoperative Nausea and Vomiting after Craniotomy: An Evidence-Based Review of General Considerations, Risk Factors and Management. J Neurosurg Anesthesiol. 2019 Dec 3.
  • Borrell-Vega J, Uribe AA, Palettas M, Bergese SD. Clevidipine use after first-line treatment failure for perioperative hypertension in neurosurgical patients: A single-center experience. Medicine (Baltimore). 2020 Jan;99(1):e18541.
  • Probst S, Corrado T, Bergese SD, Fiorella D. A dedicated cerebrovascular anesthesia team is a critical component of a comprehensive stroke center. J Neurointerv Surg. 2020 Mar;12(3):227-228.
  • Mavarez-Martinez A, Israelyan LA, Soghomonyan S, Fiorda-Diaz J, Sandhu G, Shimansky VN, Ammirati M, Palettas M, Lubnin AY, Bergese SD. The Effects of Patient Positioning on the Outcome During Posterior Cranial Fossa and Pineal Region Surgery. Front Surg. 2020 Mar 13;7:9.
  • Khanna AK, Bergese SD, Jungquist CR, Morimatsu H, Uezono S, Lee S, Ti LK, Urman RD, McIntyre R Jr, Tornero C, Dahan A, Saager L, Weingarten TN, Wittmann M, Auckley D, Brazzi L, Le Guen M, Soto R, Schramm F, Ayad S, Kaw R, Di Stefano P, Sessler DI, Uribe A, Moll V, Dempsey SJ, Buhre W, Overdyk FJ; PRediction of Opioid-induced respiratory Depression In patients monitored by capnoGraphY (PRODIGY) Group Collaborators. Prediction of Opioid-Induced Respiratory Depression on Inpatient Wards Using Continuous Capnography and Oximetry: An International Prospective, Observational Trial. Anesth Analg. 2020 Apr 16.
  • Rubano JA, Jasinski PT, Rutigliano DN, Tassiopoulos AK, Davis JE, Beg T, Poovathoor S, Bergese SD, Ahmad S, Jawa RS, Vosswinkel JA, Talamini MA. Tracheobronchial Slough, a Potential Pathology in Endotracheal Tube Obstruction in Patients with Coronavirus Disease 2019 (COVID-19) in the Intensive Care Setting. Ann Surg. 2020 May 20.
  • Turan A, Duncan A, Leung S, Karimi N, Fang J, Mao G, Hargrave J, Gillinov M, Trombetta C, Ayad S, Hassan M, Feider A, Howard-Quijano K, Ruetzler K, Sessler DI; DECADE Study Group (including Bergese S). Dexmedetomidine for reduction of atrial fibrillation and delirium after cardiac surgery (DECADE): a randomised placebo-controlled trial. Lancet. 2020 Jul 18;396(10245):177-185.
  • Weingarten TN, Morimatsu H, Fiorda-Diaz J, Bergese SD, Ariyoshi M, Sprung J, Dahan A, Overdyk FJ. New-Onset Atrial Fibrillation Detected by Continuous Capnography Monitoring: A Case Report. Am J Case Rep. 2020 Sep 19.
  • Bergese S, Berkowitz R, Rider P, Ladouceur M, Griffith S, Segura Vasi A, Cochrane K, Wase L, Demitrack MA, Habib AS. Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis. Pain Res Manag. 2020 Oct 24;2020:7492865.
  • Humeidan ML, Reyes JC, Mavarez-Martinez A, Roeth C, Nguyen CM, Sheridan E, Zuleta-Alarcon A, Otey A, Abdel-Rasoul M, Bergese SD. Effect of Cognitive Prehabilitation on the Incidence of Postoperative Delirium Among Older Adults Undergoing Major Noncardiac Surgery: The Neurobics Randomized Clinical Trial. JAMA Surg. 2020 Nov 11.
  • Bernthal NM, Hart CM, Sheth KR, Bergese SD, Ho HS, Apfel CC, Stoicea N, Rojhani A, Jahr JS. Local and Intra-articular Administration of Nonsteroidal Anti-inflammatory Drugs for Pain Management in Orthopedic Surgery. Am J Ther. 2020 Dec 10.
  • Todeschini AB, Uribe AA, Echeverria-Villalobos M, Fiorda-Diaz J, Abdel-Rasoul M, McGahan BG, Grossbach AJ, Viljoen S, Bergese SD. Efficacy of Intravenous Tranexamic Acid in Reducing Perioperative Blood Loss and Blood Product Transfusion Requirements in Patients Undergoing Multilevel Thoracic and Lumbar Spinal Surgeries: A Retrospective Study. Front Pharmacol. 2020 Nov 30;11:566956.
  • Sheth KR, Bernthal NM, Ho HS, Bergese SD, Apfel CC, Stoicea N, Jahr JS. Perioperative bleeding and non-steroidal anti-inflammatory drugs (NSAIDs): an evidence-based literature review, and current clinical appraisal. Medicine (Baltimore). 2020 Jul 31;99(31):e20042.
  • Ongaigui C, Fiorda-Diaz J, Dada O, Mavarez-Martinez A, Echeverria-Villalobos M, Bergese SD. Intraoperative Fluid Management in Patients Undergoing Spine Surgery: A Narrative Review. Front. Surg., 29 July 2020.
  • Page CR, Perez CA, Mavarez-Martinez A, Khan S, Bergese SD. Levorphanol in the Perioperative Setting: Decreasing Opioid Requirements While Improving Pain Management. J Pain Res. 2020 Oct 29;13:2721-2727.
  • Uribe AA, Bergese SD. What is the ideal combination antiemetic regimen? Best Pract Res Clin Anaesthesiol. 2020 Dec;34(4):701-712.
  • Jin Z, Gan TJ, Bergese SD. Prevention and Treatment of Postoperative Nausea and Vomiting (PONV): A Review of Current Recommendations and Emerging Therapies. Ther Clin Risk Manag. 2020 Dec 31;16:1305-1317.
  • Urman RD, Khanna AK, Bergese SD, Buhre W, Wittmann M, Le Guen M, Overdyk FJ, Di Piazza F, Saager L. Postoperative opioid administration characteristics associated with opioid-induced respiratory depression: Results from the PRODIGY trial. J Clin Anesth. 2021 Jan 22;70:110167
  • Brzezinski M, Hammer GB, Candiotti KA, Bergese SD, Pan PH, Bourne MH, Michalsky C, Wase L, Demitrack MA, Habib AS. Low Incidence of Opioid-Induced Respiratory Depression Observed with Oliceridine Regardless of Age or Body Mass Index: Exploratory Analysis from a Phase 3 Open-Label Trial in Postsurgical Pain. Pain Ther. 2021 Jan 21.
  • Khanna AK, Saager L, Bergese SD, Jungquist CR, Morimatsu H, Uezono S, Ti LK, Soto R, Jiang W, Buhre W. Opioid-induced respiratory depression increases hospital costs and length of stay in patients recovering on the general care floor. BMC Anesthesiol. 2021 Mar 20;21(1):88.
  • Jin Z, Lee C, Zhang K, Gan TJ, Bergese SD. Safety of treatment options available for postoperative pain. Expert Opin Drug Saf. 2021 Mar 3.
  • Driver CN, Laporta ML, Bergese SD, Urman RD, Di Piazza F, Overdyk FJ, Sprung J, Weingarten TN. Frequency and Temporal Distribution of Postoperative Respiratory Depressive Events Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: IMMPACT recommendations. Anesth Analg. 2021 May 1;132(5):1206-1214.
  • Chowdhury T, Gray K, Sharma M, Mau C, McNutt S, Ryan C, Farou N, Bergquist P, Caldwell C, Uribe AA, Todeschini AB, Bergese SD, Bucher O, Musto G, Azazi EA, Zadeh G, Tsang DS, Mansouri SA, Kakumanu S, Venkatraghavan L. Brain Cancer Progression: A Retrospective Multicenter Comparison of Awake Craniotomy Versus General Anesthesia in High-grade Glioma Resection. J Neurosurg Anesthesiol. 2021 May 18.
  • Soghomonyan S, Stoicea N, Bergese SD. New Trends and Approaches in Perioperative Pharmacotherapy: An Update. Front Pharmacol. 2021 Aug 6;12:721075.
  • Gupta AK, Mena S, Jin Z, Gan TJ, Bergese SD. Postoperative pain: a review of emerging therapeutic options. Expert Rev Neurother. 2021 Aug 31.
  • Jin Z, Zhu M, Gupta A, Page C, Gan TJ, Bergese SD. Evaluating oliceridine as a treatment option for moderate to severe acute post-operative pain in adults. Expert Opin Pharmacother. 2021 Sep 17.
  • Echeverria-Villalobos M, Fiorda-Diaz J, Uribe A, Bergese SD. Postoperative Nausea and Vomiting in Female Patients Undergoing Breast and Gynecological Surgery: A Narrative Review of Risk Factors and Prophylaxis. Front Med (Lausanne). 2022 Jul 1;9:909982.
  • Daksla N, Nguyen V, Jin Z, Bergese SD. Brain Prehabilitation for Oncologic Surgery. Curr Oncol Rep. 2022 Jul 28.
  • Aragón-Benedí C, Caballero-Lozada AF, Perez-Calatayud AA, Marulanda-Yanten AM, Oliver-Fornies P, Boselli E, De Jonckheere J, Bergese SD; ANI-COVID-19 Research Group. Prospective multicenter study of heart rate variability with ANI monitor as predictor of mortality in critically ill patients with COVID-19. Sci Rep. 2022 Dec 16;12(1):21762.
  • Fiorda Diaz J, Echeverria-Villalobos M, Esparza Gutierrez A, Dada O, Stoicea N, Ackermann W, Abdel-Rasoul M, Heard J, Uribe A, Bergese SD. Sugammadex versus neostigmine for neuromuscular blockade reversal in outpatient surgeries: A randomized controlled trial to evaluate efficacy and associated healthcare cost in an academic center. Front Med (Lausanne). 2022 Dec 8;9:1072711.
  • Martínez Ruíz A, Maroño Boedo MJ, Guereca Gala A, Escontrela Rodríguez BA, Bergese SD. [Zero Emissions. A shared responsibility. Gas capture and recycling project at the Cruces University Hospital (Spain)]. Rev Esp Salud Publica. 2023 Jan 9;97.
  • Daksla N, Wang A, Jin Z, Gupta A, Bergese SD. Oliceridine for the Management of Moderate to Severe Acute Postoperative Pain: A Narrative Review. Drug Des Devel Ther. 2023 Mar 22;17:875-886.
  • Jin Z, Rismany J, Gidicsin C, Bergese SD. Frailty: the perioperative and anesthesia challenges of an emerging pandemic. J Anesth. 2023 Jun 13.
  • Tsivitis A, Wang A, Murphy J, Khan A, Jin Z, Moore R, Tateosian V, Bergese S. Anesthesia, the developing brain, and dexmedetomidine for neuroprotection. Frontiers Neurol. 2023 Jun 7.
  • Ghaly L, Bargnes V, Rahman S, Tawfik GA, Bergese S, Caldwell W. Interventional Treatment of Complex Regional Pain Syndrome. Biomedicines. 2023 Aug 14;11(8):2263.
  • Hum B, Christophides A, Jin Z, Elias M, Taneja K, Bergese SD. The validity and applications of the analgesia nociception index: a narrative review. Front Surg. 2023 Aug 10.
  • Recent Presentations   
  • Uribe A, Dimitrova GT, Krouch S, Todeschini AB, Stoicea N, Munlemvo DM, Abdel-Rasoul M, Bergese S. The Effect of Thromboelastometry (ROTEM) in Patients Undergoing Complex Spine Surgeries. ASA 2019
  • Fiorda-Diaz J, Gutierrez AE, Uribe AA, Abdel-Rasoul M, Dada OF, Heard JA, Bergese SD. Sugammadex Versus Neostigmine for Neuromuscular Blockade Reversal after Outpatient Laparoscopic Surgery. ASA 2019
  • Brzezinski M, Hammer GB, Bergese SD, Pan PH, Michalsky C, Cochrane K, Wase L, Habib AS. Low Incidence of Opioid-induced Respiratory Depression Observed with Oliceridine Regardless of Age or Body Mass Index. ASA 2019
  • Bergese S, Berkowitz RD, Ladouceur M, Cochrane K, Wase L, Rider P, Habib A. Lower Incidence of Postoperative Opioid-induced Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Analysis. ASA 2019
  • Saager L, Jiang W, Khanna A, Bergese S, Morimatsu H, Uezono S, Ti LK, Soto R, Buhre W. Respiratory Depression on General Care Floors Increases Cost of Care: Results from the Prodigy Trial. ASA 2019
  • Uribe A, Todeschini AB, Fiorda-Diaz J, Echeverria-Villalobos M, Stoicea N, Viljoen S, Grossbach A, Ongaigui C, Abdel-Rasoul M, Bergese SD. Efficacy and Safety of Intravenous Tranexamic Acid in Multilevel Thoracic and Lumbar Spine Surgeries. ASA 2019
  • Bergese SD, Uribe AA, Bichajian LH, Ashburn C, Fox GM, Habib AS. Amisulpride is Effective for Rescue of Ambulatory Patients with Postoperative Nausea and Vomiting. ASA 2019
  • Driver CN, Laporta ML, Bergese SD, Urman RD, Di Piazza F, Sprung J, Weingarten TN. Temporal Distribution of Postoperative Respiratory Depression. SASM 2020
  • Laporta ML, Driver CN, Bergese SD, Urman RD, Di Piazza F, Sprung J, Weingarten TN. PRODIGY Risk Assessment Score and Frequency of Opioid-Induced Respiratory Depression. SASM 2020
  • Humeidan M, Reyes J-P, Mavarez-Martinez A, Roeth C, Nguyen C, Sheridan E, Zuleta-Alarcon A, Otey A, Abdel-Rasoul M, Bergese SD. Impact of Cognitive Exercise on Postoperative Delirium in Older Adults: the Neurobics Trial. ASA 2020
  • Urman R, Khanna AK, Bergese SD, Buhre WF, Wittmann M, Le Guen M, Overdyk FJ, Di Piazza F, Saager L. Postoperative Opioid Characteristics Associated with Respiratory Depression: Results From the Prodigy Trial. ASA 2020
  • Kang RS, Beg T, Mavarez-Martinez A, Punta C, Bergese SD. Clinical Features of COVID-19 Patients Requiring Endotracheal Tube Exchange. PGA 2020
  • Fiorda-Diaz J, Esparza Gutierrez AG, Dada O, Stoicea N, Ackermann W, Abdel-Rasoul M, Heard JA, Uribe AA, Bergese SA. Sugammadex versus Neostigmine for Neuromuscular Blockade Reversal in Outpatient Surgeries: An Evaluation of Efficacy and Associated Health Care Cost in an Academic Center. IARS 2022
  • Stoicea N, Uribe A, Ackermann W, Soghomonyan G, Bergese SD, Rogers B. QTc Interval Evaluation in Naive Methylphenidate Users: A Double-Blind Placebo-Controlled Analysis. IARS 2022
  • Mavarez-Martinez A, Stafford K, Rosenfeld J, Romeiser J, Bergese SD, Gan TJ. Efficacy of Amisulpride for Treatment of Postoperative Nausea and Vomiting in Post Anesthesia Care Unit. ASA 2022
  • Rogers B, Stoicea N, Ackermann WA, Uribe A, Abdel-Rasoul M, Brown EN, Bergese SD. Active Emergence from Isoflurane General Anesthesia Induced by Methylphenidate: A Randomized Placebo Controlled Pilot Trial. ASA 2022
  • Hum B, Shibly Y, Taneja K, Patel K, Bergese SD. Tracking Patients with Anesthesia-Related Complications: Real-World Cohort of Over 18,000 Patients. ASA 2023
  • Hum B, Shibly Y, Taneja K, Patel K, Bergese SD. Cost of Care Analysis for Patients with Opioid Use Disorder. ASA 2023