Grigori Enikolopov, PhD

Phone: 631-632-4436
Research web page
  • Education  
  • Moscow State University - M SC
  • Institute of Molecular Biology at the Russian (USSR) Academy of Sciences - Molecular Biology, PhD
  • Research Interests   
  • redox regulation of adult neural stem cells
  • adult hippocampal neurogenesis 
  • role of neural stem cells in aging, antidepressant therapies and physical activity
  • role of NO deficiency in the cilia function in the trachea
  • Publications  
  • PubMed Search
  • Rubin de Celis MF, Garcia-Martin R, Wittig D, Valencia GD, Enikolopov G, Funk RH, Chavakis T, Bornstein SR, Androutsellis-Theotokis A, Ehrhart-Bornstein M. Multipotent glia-like stem cells mediate stress adaptation. Stem Cells. 2015 Jun;33(6):2037-51
  • Park MH, Jin HK, Min WK, Lee WW, Lee JE, Akiyama H, Herzog H, Enikolopov GN, Schuchman EH, Bae JS. Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow. EMBO J. 2015 Jun 12;34(12):1648-60
  • Makaryus R, Lee H, Feng T, Park J-H, Nedergaard M, Jacob Z, Enikolopov G, Benveniste H. Brain maturation in neonatal rodents is impeded by sevoflurane anesthesia. Anesthesiology. 2015 Sep;123(3):557-68
  • Wang H, Warner-Schmidt J, Varela S, Enikolopov G, Greengard P, Flajolet M. Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9745-50
  • Enikolopov G, Overstreet-Wadiche L, Ge S. Viral and Transgenic Reporters and Genetic Analysis of Adult Neurogenesis. Cold Spring Harb Perspect Biol. 2015 Aug 3;7(8)
  • Matlashov ME, Bogdanova YA, Ermakova GV, Mishina NM, Ermakova YG, Nikitin ES, Balaban PM, Okabe S, Lukyanov S, Enikolopov G, Zaraisky AG, Belousov VV. Fluorescent ratiometric pH indicator SypHer2: applications in neuroscience and regenerative biology.. Biochim Biophys Acta. 2015 Nov;1850(11):2318-28
  • Shin J, Berg DA, Zhu Y, Shin JY, Song J, Bonaguidi MA, Enikolopov G, Nauen DW, Christian KM, Ming GL, Song H. Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis. Cell Stem Cell. 2015 Sep 3;17(3):360-72
  • Smagin DA, Park JH, Michurina TV, Peunova N, Glass Z, Sayed K, Bondar NP, Kovalenko IN, Kudryavtseva NN, Enikolopov G. Altered Hippocampal Neurogenesis and Amygdalar Neuronal Activity in Adult Mice with Repeated Experience of Aggression. Front Neurosci. 2015 Dec 1;9:443
  • Saboor F, Reckmann AN, Tomczyk CU, Peters DM, Weissmann N, Kaschtanow A, Schermuly RT, Michurina TV, Enikolopov G, Müller D, Mietens A, Middendorff R. Nestin-expressing vascular wall cells drive development of pulmonary hypertension. Eur Respir J. 2016 Mar;47(3):876-88
  • Licht T, Rothe G, Kreisel T, Wolf B, Benny O, Rooney AG, Ffrench-Constant C, Enikolopov G, Keshet E. VEGF preconditioning leads to stem cell remodeling and attenuates age-related decay of adult hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2016 Nov 14
  • Mignone J, Peunova N, Enikolopov G. Nestin-Based Reporter Transgenic Mouse Lines. Methods Mol Biol. 2016;1453:7-14
  • Koning JJ, Konijn T, Lakeman KA, O'Toole T, Kenswil KJ, Raaijmakers MH, Michurina TV, Enikolopov G, Mebius RE. Nestin-Expressing Precursors Give Rise to Both Endothelial as well as Nonendothelial Lymph Node Stromal Cells. J Immunol. 2016 Oct 1;197(7):2686-94
  • Barykina NV, Subach OM, Doronin DA, Sotskov VP, Roshchina MA, Kunitsyna TA, Malyshev AY, Smirnov IV, Azieva AM, Sokolov IS, Piatkevich KD, Burtsev MS, Varizhuk AM, Pozmogova GE, Anokhin KV, Subach FV, Enikolopov GN. A new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites. Sci Rep. 2016 Sep 28;6:34447
  • Kulkarni S, Micci MA, Leser J, Shin C, Tang SC, Fu YY, Liu L, Li Q, Saha M, Li C, Enikolopov G, Becker L, Rakhilin N, Anderson M, Shen X, Dong X, Butte MJ, Song H, Southard-Smith EM, Kapur RP, Bogunovic M, Pasricha PJ. Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis. Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3709-E3718.
  • Barykina NV, Subach OM, Piatkevich KD, Jung EE, Malyshev AY, Smirnov IV, Bogorodskiy AO, Borshchevskiy VI, Varizhuk AM, Pozmogova GE, Boyden ES, Anokhin KV, Enikolopov GN, Subach FV. Green fluorescent genetically encoded calcium indicator based on calmodulin/M13-peptide from fungi. PLoS One. 2017 Aug 24;12(8):e0183757.
  • Akishina AA, Vorontsova JE, Cherezov RO, Mertsalov IB, Zatsepina OG, Slezinger MS, Panin VM, Petruk S, Enikolopov GN, Mazo A, Simonova OB, Kuzin BA. Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers. Oncotarget. 2017 Oct 31;8(61):102934-102947.
  • Shuvaev SA, Lazutkin AA, Kedrov AV, Anokhin KV, Enikolopov GN, Koulakov AA. DALMATIAN: An Algorithm for Automatic Cell Detection and Counting in 3D. Front Neuroanat. 2017 Dec 12;11:117.
  • Podgorny O, Peunova N, Park JH, Enikolopov G. Triple S-Phase Labeling of Dividing Stem Cells. Stem Cell Reports. 2018 Jan 17.
  • Doronin DA, Barykina NV, Subach OM, Sotskov VP, Plusnin VV, Ivleva OA, Isaakova EA, Varizhuk AM, Pozmogova GE, Malyshev AY, Smirnov IV, Piatkevich KD, Anokhin KV, Enikolopov GN, Subach FV. Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics. BMC Biotechnol. 2018 Feb 13;18(1):10.
  • Mineyeva OA, Enikolopov G, Koulakov AA.. Spatial geometry of stem cell proliferation in the adult hippocampus. Sci Rep. 2018 Feb 21;8(1):3444.
  • Makaryus R, Lee H, Robinson J, Enikolopov G, Benveniste H. Noninvasive Tracking of Anesthesia Neurotoxicity in the Developing Rodent Brain. Anesthesiology. 2018 Apr 24.
  • Podgorny O, Peunova N, Enikolopov G. Tracing dividing stem cells. Aging (Albany NY). 2018 Jul 1;10(7):1534-1535.
  • Mineyeva O, Koulakov A, Enikolopov G. Neural stem cell spacing questions their self-renewal. Aging (Albany NY). 2018 Aug 9.
  • Barykina NV, Doronin DA, Subach OM, Sotskov VP, Plusnin VV, Ivleva OA, Gruzdeva AM, Kunitsyna TA, Ivashkina OI, Lazutkin AA, Malyshev AY, Smirnov IV, Varizhuk AM, Pozmogova GE, Piatkevich KD, Anokhin KV, Enikolopov G, Subach FV. NTnC-like genetically encoded calcium indicator with a positive and enhanced response and fast kinetics. Sci Rep. 2018 Oct 15;8(1):15233.
  • Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, KrŸger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D. Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis. Cell Metab. 2018 Dec 28.
  • Mineyeva OA, Bezriadnov DV, Kedrov AV, Lazutkin AA, Anokhin KV, Enikolopov GN. Radiation Induces Distinct Changes in Defined Subpopulations of Neural Stem and Progenitor Cells in the Adult Hippocampus. Front Neurosci. 2019 Jan 9;12:1013.
  • Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, Sun X, Sandhow L, Artemov AV, Ivashkin E, Suter S, Dyachuk V, El Shahawy M, Gritli-Linde A, Bouderlique T, Petersen J, Mollbrink A, Lundeberg J, Enikolopov G, Qian H, Fried K, Kasper M, Hedlund E, Adameyko I, SŠvendahl L, Chagin AS. A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate. Nature. 2019 Feb 27.
  • Lazutkin A, Podgorny O, Enikolopov G. Modes of division and differentiation of neural stem cells. Behav Brain Res. 2019 Jul 29:112118.
  • Kedrov AV, Mineyeva OA, Enikolopov GN, Anokhin KV. Involvement of Adult-born and Preexisting Olfactory Bulb and Dentate Gyrus Neurons in Single-trial Olfactory Memory Acquisition and Retrieval. Neuroscience. 2019 Oct 28. pii: S0306-4522(19)30657-8.
  • Fu CH, Iascone DM, Petrof I, Hazra A, Zhang X, Pyfer MS, Tosi U, Corbett BF, Cai J, Lee J, Park J, Iacovitti L, Scharfman HE, Enikolopov G, Chin J. Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model. Cell Rep. 2019 Jun 25;27(13):3741-3751.
  • Subach OM, Kunitsyna TA, Mineyeva OA, Lazutkin AA, Bezryadnov DV, Barykina NV, Piatkevich KD, Ermakova YG, Bilan DS, Belousov VV, Anokhin KV, Enikolopov GN, Subach FV. Slowly Reducible Genetically Encoded Green Fluorescent Indicator for In Vivo and Ex Vivo Visualization of Hydrogen Peroxide. Int J Mol Sci. 2019 Jun 27;20(13).
  • Mikhailik A, Michurina TV, Dikranian K, Hearn S, Maxakov VI, Siller SS, Takemaru K-I, Enikolopov G, Peunova N. nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea. Life Sci Alliance. 2021 Mar 2;4(5):e202000981.
  • Maltsev DI, Mellanson KA, Belousov VV, Enikolopov GN, Podgorny OV. The bioavailability time of commonly used thymidine analogues after intraperitoneal delivery in mice: labeling kinetics in vivo and clearance from blood serum. Histochem Cell Biol. 2021 Nov 10.
  • Xue Y, Gursky Z, Monte B, Koundal S, Liu X, Lee H, Michurina TV, Mellanson KA, Zhao L, Nemajerova A, Kahle KT, Takemaru KI, Enikolopov G, Peunova NI, Benveniste H. Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus. Fluids Barriers CNS. 2022 Mar 5;19(1):20.
  • Shuvaev S, Lazutkin A, Kiryanov R, Anokhin K, Enikolopov G, Koulakov AA. Spatiotemporal 3D image registration for mesoscale studies of brain development. Sci Rep. 2022 Mar 7;12(1):3648.
  • Ivanova A, Gruzova O, Ermolaeva E, Astakhova O, Itaman S, Enikolopov G, Lazutkin A. Synthetic Thymidine Analog Labeling without Misconceptions. Cells. 2022 Jun 10;11(12):1888
  • Chandrakanthan V, Rorimpandey P, Zanini F, Chacon D, Olivier J, Joshi S, Kang YC, Knezevic K, Huang Y, Qiao Q, Oliver RA, Unnikrishnan A, Carter DR, Lee B, Brownlee C, Power C, Brink R, Mendez-Ferrer S, Enikolopov G, Walsh W, Göttgens B, Taoudi S, Beck D, Pimanda JE. Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta. Nat Cell Biol. 2022 Jul 28.
  • Itaman S, Enikolopov G, Podgorny OV. Detection of De Novo Dividing Stem Cells In Situ through Double Nucleotide Analogue Labeling. Cells. 2022 Dec 10;11(24):4001.
  • Amelchenko EM, Bezriadnov DV, Chekhov OA, Ivanova AA, Kedrov AV, Anokhin KV, Lazutkin AA, Enikolopov G. Cognitive flexibility is selectively impaired by radiation and is associated with differential recruitment of adult-born neurons. J Neurosci. 2023 Aug 1:JN-RM-0161-22
  • Amelchenko EM, Bezriadnov DV, Chekhov OA, Anokhin KV, Lazutkin AA, Enikolopov G. Age-related decline in cognitive flexibility is associated with the levels of hippocampal neurogenesis. Front Neurosci. 2023 Aug 14;17.

photo by Jeanne Neville