Martin Kaczocha, PhD


Associate Professor

Phone: 631-444-6077
Email
Research Web Page
  • Education  
  • Stony Brook University, Biochemistry and Cell Biology, PhD
  • Stony Brook University, Biochemistry and Cell Biology, Postdoc
  • Awards, Honors, Professional Appointments   
  • Associate Editor, BMC Anesthesiology
  • Winner of the "Young Academic Inventor's Award" by the Stony Brook chapter of the National Academy of Inventors
  • Research Interests   
  • Role of FABPs in inflammatory pain
  • Modulation of brain endocannabinoid signaling by FABPs
  • Endocannabinoid metabolism and postsurgical pain
  • FABPs and cancer
  • Control of phytocannabinoid signaling by FABPs
  • Publications   
  • PubMed Search
  • Azim S, Nicholson J, Rebecchi MJ, Galbavy W, Feng T, Reinsel R, Volkow ND, Benveniste H, Kaczocha M. Endocannabinoids and acute pain after total knee arthroplasty. Pain. 2015 Feb;156(2):341-347
  • Elmes MW, Kaczocha M, Berger WT, Leung K, Ralph BP, Wang L, Sweeney JM, Miyauchi JT, Tsirka SE, Ojima I, Deutsch DG.. Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD).. J Biol Chem. 2015 Apr 3;290(14):8711-21.
  • Nicholson J, Azim S, Rebecchi MJ, Galbavy W, Feng T, Reinsel R, Rizwan S, Fowler CJ, Benveniste H, Kaczocha M. Leptin Levels Are Negatively Correlated with 2-Arachidonoylglycerol in the Cerebrospinal Fluid of Patients with Osteoarthritis.. PLoS One. 2015 Apr 2;10(4)
  • Sirrs S, van Karnebeek CD, Peng X, Shyr C, Tarailo-Graovac M, Mandal R, Testa D, Dubin D, Carbonetti G, Glynn SE, Sayson B, Robinson WP, Han B, Wishart D, Ross CJ, Wasserman WW, Hurwitz TA, Sinclair G, Kaczocha M.. Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms.. Orphanet J Rare Dis. 2015 Mar 28;10(1):38
  • Galbavy W, Kaczocha M, Puopolo M, Liu L, Rebecchi MJ. Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. PLoS One. 2015 Aug 4;10(8)
  • Kaczocha M, Glaser ST, Maher T, Clavin B, Hamilton J, O'Rourke J, Rebecchi M, Puopolo M, Owada Y, Thanos PK. Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms. Mol Pain. 2015 Aug 28;11(1):52
  • Chakraborty S, Rebecchi M, Kaczocha M, Puopolo M. Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons. J Physiol. 2016 Mar 15;594(6):1627-42
  • Thanos PK, Clavin BH, Hamilton J, O'Rourke JR, Maher T, Koumas C, Miao E, Lankop J, Elhage A, Haj-Dahmane S, Deutsch D, Kaczocha M. Examination of the Addictive and Behavioral Properties of Fatty Acid-Binding Protein Inhibitor SBFI26. Front Psychiatry. 2016 Apr 5;7:54
  • Martin GG, Chung S, Landrock D, Landrock KK, Dangott LJ, Peng X, Kaczocha M, Murphy EJ, Kier AB, Schroeder F. Female Mice are Resistant to FABP1 Gene Ablation-Induced Alterations in Brain Endocannabinoid Levels. Lipids. 2016 Sep;51(9):1007-20
  • Chakraborty S, Elvezio V, Kaczocha M, Rebecchi M, Puopolo M. Presynaptic inhibition of transient receptor potential vanilloid type 1 (TRPV1) receptors by norepinephrine in nociceptive neurons. J Physiol. 2017 Jan 17
  • Peng X, Studholme K, Kanjiya MP, Luk J, Bogdan D, Elmes MW, Carbonetti G, Tong S, Gary Teng YH, Rizzo RC, Li H, Deutsch DG, Ojima I, Rebecchi MJ, Puopolo M, Kaczocha M. Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms. Mol Pain. 2017 Jan;13
  • Galbavy W, Lu Y, Kaczocha M, Puopolo M, Liu L, Rebecchi MJ. Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord. Immun Ageing. 2017 Apr 13;14:9
  • Hsu HC, Tong S, Zhou Y, Elmes MW, Yan S, Kaczocha M, Deutsch DG, Rizzo RC, Ojima I, Li H. The antinociceptive agent SBFI-26 binds to anandamide transporters FABP5 and FABP7 at two different sites. Biochemistry. 2017 Jul 11;56(27):3454-3462
  • Figueiredo A, Hamilton J, Marion M, Blum K, Kaczocha M, Haj-Dahmane S, Deutsch D, Thanos PK. Pharmacological Inhibition of Brain Fatty Acid Binding Protein Reduces Ethanol Consumption in Mice. J Reward Defic Syndr Addict Sci. 2017;3(2):21-27
  • Azim S, Nicholson J, Rebecchi MJ, Galbavy W, Feng T, Rizwan S, Reinsel RA, Kaczocha M, Benveniste H. Interleukin-6 and leptin levels are associated with preoperative pain severity in patients with osteoarthritis but not with acute pain after total knee arthroplasty. Knee. 2018 Jan 8
  • Bogdan D, Falcone J, Kanjiya MP, Park SH, Carbonetti G, Studholme K, Gomez M, Lu Y, Elmes MW, Smietalo N, Yan S, Ojima I, Puopolo M, Kaczocha M. Fatty acid binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation. J Biol Chem. 2018 Feb 13
  • Hamilton J, Marion M, Figueiredo A, Clavin BH, Deutsch D, Kaczocha M, Haj-Dahmane S, Thanos PK.. Fatty acid binding protein deletion prevents stress-induced preference for cocaine and dampens stress-induced corticosterone levels.. Synapse. 2018 Feb 19
  • Kaczocha M, Azim S, Nicholson J, Rebecchi MJ, Lu Y, Feng T, Romeiser JL, Reinsel R, Rizwan S, Shodhan S, Volkow ND, Benveniste H.. Intrathecal morphine administration reduces postoperative pain and peripheral endocannabinoid levels in total knee arthroplasty patients: a randomized clinical trial.. BMC Anesthesiol. 2018 Feb 27;18(1):27
  • Haj-Dahmane S, Shen RY, Elmes MW, Studholme K, Kanjiya MP, Bogdan D, Thanos PK, Miyauchi JT, Tsirka SE, Deutsch DG, Kaczocha M. Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses. Proc Natl Acad Sci U S A. 2018 Mar 12
  • Luk J, Lu Y, Ackermann A, Peng X, Bogdan D, Puopolo M, Komatsu DE, Tong S, Ojima I, Rebecchi MJ, Kaczocha M. Contribution of diacylglycerol lipase beta to pain after surgery. J Pain Res. 2018 Mar 5;11:473-482
  • Hamilton J, Koumas C, Clavin BH, Marion M, Figueiredo A, Gonzalez S, O'Rourke JR, Deutsch D, Kaczocha M, Haj-Dahmane S, Thanos PK. Fatty acid-binding proteins 5 and 7 gene deletion increases sucrose consumption and diminishes forced swim immobility time. Behav Pharmacol. 2018 Mar 21
  • Elmes MW, Volpe AD, d'Oelsnitz S, Sweeney JM, Kaczocha M. Lipocalin-Type Prostaglandin D Synthase Is a Novel Phytocannabinoid-Binding Protein. Lipids. 2018 Mar;53(3):353-360.
  • Yan S, Elmes MW, Tong S, Hu K, Awwa M, Teng GYH, Jing Y, Freitag M, Gan Q, Clement T, Wei L, Sweeney JM, Joseph OM, Che J, Carbonetti GS, Wang L, Bogdan DM, Falcone J, Smietalo N, Zhou Y, Ralph B, Hsu HC, Li H, Rizzo RC, Deutsch DG, Kaczocha M, Ojima I. SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins. Eur J Med Chem. 2018 May 24;154:233-252.
  • Lu Y, Doroshenko M, Lauzadis J, Kanjiya MP, Rebecchi M, Kaczocha M, Puopolo M. Presynaptic inhibition of primary nociceptive signals to dorsal horn lamina I neurons by dopamine. J Neurosci. 2018 Aug 24.
  • Azim S, Nicholson J, Rebecchi MJ, Galbavy W, Feng T, Rizwan S, Reinsel RA, Kaczocha M, Benveniste H. Interleukin-6 and leptin levels are associated with preoperative pain severity in patients with osteoarthritis but not with acute pain after total knee arthroplasty. Knee. 2018 Jan;25(1):25-33.
  • Elmes MW, Prentis LE, McGoldrick LL, Giuliano CJ, Sweeney JM, Joseph OM, Che J, Carbonetti GS, Studholme K, Deutsch DG, Rizzo RC, Glynn SE, Kaczocha M. FABP1 controls hepatic transport and biotransformation of Δ9-THC. Sci Rep. 2019 May 20;9(1):7588.
  • Zhou Y, Elmes MW, Sweeney J, Joseph O, Che J, Hsu HC, Li H, Deutsch DG, Ojima I, Kaczocha M, Rizzo RC. Identification of Fatty Acid Binding Protein 5 Inhibitors Through Similarity-based Screening. Biochemistry. 2019 Sep 20.
  • Carbonetti G, Wilpshaar T, Kroonen J, Studholme K, Converso C, d'Oelsnitz S, Kaczocha M. FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. Sci Rep. 2019 Dec 12;9(1):18944.
  • Kim J, Bogdan DM, Elmes MW, Awwa M, Yan S, Che J, Lee G, Deutsch DG, Rizzo RC, Kaczocha M, Ojima I. Incarvillateine produces antinociceptive and motor suppressive effects via adenosine receptor activation. PLoS One. 2019 Jun 25;14(6):e0218619.
  • Carbonetti G, Converso C, Clement T, Wang C, Trotman LC, Ojima I, Kaczocha M. Docetaxel/cabazitaxel and fatty acid binding protein 5 inhibitors produce synergistic inhibition of prostate cancer growth. Prostate. 2020 Jan;80(1):88-98.
  • Lauzadis J, Liu H, Yong L, Rebecchi MJ, Kaczocha M, Puopolo M. Contribution of T-type calcium channels to spinal cord injury induced hyperexcitability of nociceptors. J Neurosci. 2020 Aug 24.
  • Miller S, Daily L, Dharla V, Gertsch J, Malamas MS, Ojima I, Kaczocha M, Ogasawara D, Straiker A. Endocannabinoid metabolism and transport as targets to regulate intraocular pressure. Exp Eye Res. 2020 Sep 23:108266.
  • O'Sullivan SE, Kaczocha M. FABP5 as a novel molecular target in prostate cancer. Drug Discov Today. 2020 Sep 20:S1359-6446.
  • Kaczocha M, Haj-Dahmane S. Mechanisms of Endocannabinoid Transport in the Brain. Br J Pharmacol. 2021 Mar 30.
  • Bogdan DM, Studholme K, DiBua A, Gordon C, Kanjiya MP, Yu M, Puopolo M, Kaczocha M. FABP5 deletion in nociceptors augments endocannabinoid signaling and suppresses TRPV1 sensitization and inflammatory pain. Sci Rep. 2022 Jun 2;12(1):9241
  • Fauzan M, Oubraim S, Yu M, Glaser ST, Kaczocha M, Haj-Dahmane S. Fatty Acid-Binding Protein 5 Modulates Brain Endocannabinoid Tone and Retrograde Signaling in the Striatum. Front Cell Neurosci. 2022 Jul 7.
  • Liu X, Bae C, Liu B, Zhang YM, Zhou X, Zhang D, Zhou C, DiBua A, Schutz L, Kaczocha M, Puopolo M, Yamaguchi TP, Chung JM, Tang SJ. Development of opioid-induced hyperalgesia depends on reactive astrocytes controlled by Wnt5a signaling. Mol Psychiatry. 2022 Oct 6.
  • Oubraim S, Wang R, Hausknecht K, Kaczocha M, Shen RY, Haj-Dahmane S. Prenatal ethanol exposure causes anxiety-like phenotype and alters synaptic nitric oxide and endocannabinoid signaling in dorsal raphe nucleus of adult male rats. Transl Psychiatry. 2022 Oct 10;12(1):440.
  • Wang H, Taouil A, Awwa M, Clement T, Zhu C, Kim J, Rendina D, Jayanetti K, Maharaj A, Wang L, Bogdan D, Pepe A, Kaczocha M, Ojima I. SAR study on Novel truxillic acid monoester-Based inhibitors of fatty acid binding proteins as Next-Generation antinociceptive agents. Bioorg Chem. 2022 Sep 30;129:106184.
  • Komatsu DE, Uddin SMZ, Gordon C, Kanjiya MP, Bogdan D, Achonu J, DiBua A, Iftikhar H, Ackermann A, Shah RJ, Shieh J, Bialkowska AB, Kaczocha M. Acute postoperative pain and dorsal root ganglia transcriptomic signatures following total knee arthroplasty (TKA) in rats: An experimental study. PLoS One. 2022 Dec 6;17(12):e0278632.
  • Liu H, Lauzadis J, Gunaratna K, Sipple E, Kaczocha M, Puopolo M. Inhibition of T-type calcium channels with TTA-P2 reduces chronic neuropathic pain following spinal cord injury in rats. J Pain. 2023 May 9.
  • Yu M, Gordon C, Studholme K, Hassan M, Sadar F, Khan A, Nicholson J, Komatsu DE, Kaczocha M. Monoacylglycerol Lipase and Cyclooxygenase-2 Expression in Osteoarthritic Human Knees. Cannabis Cannabinoid Res. 2023 Jun 26.
  • Glaser ST, Jayanetti K, Oubraim S, Hillowe A, Frank E, Jong J, Wang L, Wang H, Ojima I, Haj-Dahmane S, Kaczocha M. Fatty acid binding proteins are novel modulators of synaptic epoxyeicosatrienoic acid signaling in the brain. Sci Rep. 2023 Sep 14;13(1):15234.
  • Zhu C, Schutz L, Jayanetti K, Takemura K, Doswell F, Wang L, Ojima I, Kaczocha M. Truxillic acid monoamides as fatty acid binding protein 5 inhibitors. Bioorg Med Chem. 2023 Sep 4;94:117464.
  • Hillowe A, Gordon C, Wang L, Rizzo RC, Trotman LC, Ojima I, Bialkowska A, Kaczocha M. Fatty acid binding protein 5 regulates docetaxel sensitivity in taxane-resistant prostate cancer cells. PLoS One. 2023 Oct 5;18(10).
  • Gordon C, Trainor J, Shah RJ, Studholme K, Gelman A, Doswell F, Sadar F, Giovannetti A, Gershenson J, Khan A, Nicholson J, Huang Z, Spurgat M, Tang SJ, Wang H, Ojima I, Carlson D, Komatsu DE, Kaczocha M. Fatty acid binding protein 5 inhibition attenuates pronociceptive cytokine/chemokine expression and suppresses osteoarthritis pain: A comparative human and rat study. Osteoarthritis Cartilage. 2023 Nov 28:S1063-4584.
  • Hwang SM, Awasthi D, Jeong J, Sandoval T, Chae CS, Ramos Y, Tan C, Falco MM, McBain I, Mishra B, Ivashkiv LB, Zamarin D, Cantillo E, Chapman-Davis E, Holcomb K, Morales D, Rodriguez P, Conejo-Garcia J, Kaczocha M, Vähärautio A, Song M, Cubillos-Ruiz J. Transgelin 2 guards T cell lipid metabolic programming and anti-tumor function. Res Sq. 2023 Dec 14.
  • Swamynathan M, Mathew G, Aziz A, Gordon C, Hillowe A, Wang H, Jhaveri A, Kendall J, Cox H, Giarrizzo M, Azabdaftari G, Rizzo RC, Diermeier SD, Ojima I, Bialkowska AB, Kaczocha M, Trotman LC. FABP5 Inhibition against PTEN-Mutant Therapy Resistant Prostate Cancer. Cancers (Basel). 2023 Dec 21;16(1):60.
  • Warren G, Osborn M, Tsantoulas C, David-Pereira A, Cohn D, Duffy P, Ruston L, Johnson C, Bradshaw H, Kaczocha M, Ojima I, Yates A, O'Sullivan SE. Discovery and Preclinical Evaluation of a Novel Inhibitor of FABP5, ART26.12, Effective in Oxaliplatin-Induced Peripheral Neuropathy. J Pain. 2024 Jan 15:S1526-5900.
  • Sun J, Esplugues E, Bort A, Cardelo MP, Ruz-Maldonado I, Fernández-Tussy P, Wong C, Wang H, Ojima I, Kaczocha M, Perry R, Suárez Y, Fernández-Hernando C. Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring. Nat Metab. 2024 Apr 25.
  • Doswell F, Haley JD, Kaczocha M. Proteomic Analysis of Signaling Pathways Modulated by FABP5 in Macrophages. J Pharmacol Exp Ther. 2024 Jun 7:JPET-AR-2023-002006.
  • Sideris A, Lauzadis J, Kaczocha M. The Basic Science of Cannabinoids. Anesth Analg. 2024 Jan 1;138(1):42-53.
  • Murphy J, Pak S, Shteynman L, Winkeler I, Jin Z, Kaczocha M, Bergese SD. Mechanisms and Preventative Strategies for Persistent Pain following Knee and Hip Joint Replacement Surgery: A Narrative Review. Int J Mol Sci. 2024 Apr 26;25(9):4722.
  • Recent Presentations   
  • Jones MJ, Uzuneser TC, Kaczocha M, Ojima I, Laviolett SR. A novel FABP5 inhibitor modulates anxiety-related signaling patterns in the basolateral amygdala-prefrontal cortical-hippocampal circuitry. Society for Neuroscience 2021
  • Uzuneser TC, Szkudlarek HJ, Jones MJ, Nashed MG, Kaczocha M, Ojima I, Laviolette SR. Inhibition of fatty acid binding protein-5 in the prefrontal cortex reduces fear and anxiety responses by distinct endocannabinoid receptor-mediated mechanisms. Society for Neuroscience 2021
  • Puopolo M, Liu H, Lauzadis J, Kaczocha M. Contribution of T-type calcium channels to nociceptors’ hyperexcitability and chronic neuropathic pain following spinal cord injury in rats. Society for Neuroscience 2021
  • Gunaratna K, Liu H, Sipple E, Lauzadis J, Kaczocha M, Puopolo M. Contribution of CaV3.2 calcium channels to nociceptors’ hyperexcitability and chronic neuropathic pain following spinal cord injury. Society for Neuroscience 2022
  • Sipple E, Liu H, Gunaratna K, Lauzadis J, Kaczocha M, Puopolo M. Targeting T-type calcium channels and the endocannabinoid system to treat SCI-induced neuropathic pain. Society for Neuroscience 2022
  • Oubraim S, Wang R, Hausknecht KA, Kaczocha M, Shen R-Y, Haj-Dahmane S. Maternal Ethanol Exposure Causes Anxiety Phenotype and Alters Synaptic Nitric Oxide and Endocannabinoid Signaling in Dorsal Raphe Nucleus of Adult Male Offspring Rats. Society for Neuroscience 2022
  • Oster S, Espeleta J, Divaris H, Landman S, Khan M, Bhan R, Christophides A, Stanley S, Singh SM, Kaczocha M, Bennett-Guerrero E, Komatsu DE. Assessing Variability In Pre-Operative Self-Reported Pain. PGA 2022
  • Espeleta J, Oster S, Divaris H, Landman S, Khan M, Stanley S, Singh SM, Kaczocha M, Bennett-Guerrero E, Komatsu DE. Assessing Variability In Preoperative Self-Reported Pain. ASA 2023
  • Sipple E, Gunaratna K, Liu H, Lauzadis J, Kaczocha M, Puopolo M. Inhibition of endocannabinoid catabolizing enzyme fatty acid amide hydrolase to reduce chronic neuropathic pain following spinal cord injury. Society for Neuroscience 2023