Michelino Puopolo, PhD

Associate Professor
Phone: 631-638-2145
Email
Research Web Page
  • Education  
  • University of Bologna, Italy - Biology
  • University of Ferrara, Italy - PhD Neurobiology & Neurophysiology
  • Department of Neurobiology, Harvard Medical School - Postdoc
  • Research Interests  
  • Ion channels and neuronal excitability
  • mechanisms of pain
  • Awards, Honors, Professional Appointments  
  • Associate Editor, BMC Anesthesiology
  • Publications  
  • PubMed Search
  • Kaczocha M, Glaser ST, Maher T, Clavin B, Hamilton J, O'Rourke J, Rebecchi M, Puopolo M, Owada Y, Thanos PK. Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms. Mol Pain. 2015 Aug 28;11(1):52
  • Galbavy W, Kaczocha M, Puopolo M, Liu L, Rebecchi MJ. Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. PLoS One. 2015 Aug 4;10(8)
  • Chakraborty S, Rebecchi M, Kaczocha M, Puopolo M. Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons. J Physiol. 2016 Mar 15;594(6):1627-42
  • Chakraborty S, Elvezio V, Kaczocha M, Rebecchi M, Puopolo M. Presynaptic inhibition of transient receptor potential vanilloid type 1 (TRPV1) receptors by norepinephrine in nociceptive neurons. J Physiol. 2017 Jan 17.
  • Peng X, Studholme K, Kanjiya MP, Luk J, Bogdan D, Elmes MW, Carbonetti G, Tong S, Gary Teng YH, Rizzo RC, Li H, Deutsch DG, Ojima I, Rebecchi MJ, Puopolo M, Kaczocha M. Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms. Mol Pain. 2017 Jan;13.
  • Galbavy W, Lu Y, Kaczocha M, Puopolo M, Liu L, Rebecchi MJ. Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord. Immun Ageing. 2017 Apr 13;14:9.
  • Bogdan D, Falcone J, Kanjiya MP, Park SH, Carbonetti G, Studholme K, Gomez M, Lu Y, Elmes MW, Smietalo N, Yan S, Ojima I, Puopolo M, Kaczocha M. Fatty acid binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation. J Biol Chem. 2018 Feb 13.
  • Luk J, Lu Y, Ackermann A, Peng X, Bogdan D, Puopolo M, Komatsu DE, Tong S, Ojima I, Rebecchi MJ, Kaczocha M. Contribution of diacylglycerol lipase beta to pain after surgery. J Pain Res. 2018 Mar 5;11:473-482.
  • Lu Y, Doroshenko M, Lauzadis J, Kanjiya MP, Rebecchi M, Kaczocha M, Puopolo M. Presynaptic inhibition of primary nociceptive signals to dorsal horn lamina I neurons by dopamine. J Neurosci. 2018 Aug 24.
  • Puopolo M. The hypothalamic-spinal dopaminergic system: a target for pain modulation. Neural Regen Res. 2019 Jun;14(6):925-930.
  • Lee S, Jo S, Talbot S, Zhang HB, Kotoda M, Andrews NA, Puopolo M, Liu PW, Jacquemont T, Pascal M, Heckman LM, Jain A, Lee J, Woolf CJ, Bean BP. Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation. Elife. 2019 Nov 25;8. pii: e48118.
  • Lauzadis J, Liu H, Yong L, Rebecchi MJ, Kaczocha M, Puopolo M. Contribution of T-type calcium channels to spinal cord injury induced hyperexcitability of nociceptors. J Neurosci. 2020 Aug 24.
  • Yang NJ, Isensee J, Neel DV, Quadros AU, Zhang HB, Lauzadis J, Liu SM, Shiers S, Belu A, Palan S, Marlin S, Maignel J, Kennedy-Curran A, Tong VS, Moayeri M, Röderer P, Nitzsche A, Lu M, Pentelute BL, Brüstle O, Tripathi V, Foster KA, Price TJ, Collier RJ, Leppla SH, Puopolo M, Bean BP, Cunha TM, Hucho T, Chiu IM. Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons. Nat Neurosci. 2021 Dec 20.
  • Shin SM, Lauzadis J, Itson-Zoske B, Cai Y, Fan F, Natarajan G, Kwok WM, Puopolo M, Hogan QH, Yu H. Targeting intrinsically disordered regions facilitates discovery of CaV3.2 inhibitory peptides for AAV-mediated peripheral analgesia. Pain. 2022 Apr 14.
  • Bogdan DM, Studholme K, DiBua A, Gordon C, Kanjiya MP, Yu M, Puopolo M, Kaczocha M. FABP5 deletion in nociceptors augments endocannabinoid signaling and suppresses TRPV1 sensitization and inflammatory pain. Sci Rep. 2022 Jun 2;12(1):9241
  • Liu X, Bae C, Liu B, Zhang YM, Zhou X, Zhang D, Zhou C, DiBua A, Schutz L, Kaczocha M, Puopolo M, Yamaguchi TP, Chung JM, Tang SJ. Development of opioid-induced hyperalgesia depends on reactive astrocytes controlled by Wnt5a signaling. Mol Psychiatry. 2022 Oct 6.
  • Liu H, Lauzadis J, Gunaratna K, Sipple E, Kaczocha M, Puopolo M. Inhibition of T-type calcium channels with TTA-P2 reduces chronic neuropathic pain following spinal cord injury in rats. J Pain. 2023 May 9.
  • Recent Presentations  
  • Puopolo M, Liu H, Lauzadis J. Contribution of hypothalamic A11 dopaminergic neurons to pain modulation in the dorsal horn of the spinal cord. Society for Neuroscience 2019
  • Puopolo M, Liu H, Lauzadis J, Kaczocha M. Contribution of T-type calcium channels to nociceptors’ hyperexcitability and chronic neuropathic pain following spinal cord injury in rats. Society for Neuroscience 2021
  • Gunaratna K, Liu H, Sipple E, Lauzadis J, Kaczocha M, Puopolo M. Contribution of CaV3.2 calcium channels to nociceptors’ hyperexcitability and chronic neuropathic pain following spinal cord injury. Society for Neuroscience 2022
  • Sipple E, Liu H, Gunaratna K, Lauzadis J, Kaczocha M, Puopolo M. Targeting T-type calcium channels and the endocannabinoid system to treat SCI-induced neuropathic pain. Society for Neuroscience 2022