Shao-Jun Tang, PhD

Stony Brook Medicine Endowed Professorship in Anesthesiology
Vice Chair for Research
Director of The Stony Brook University Pain and Analgesia Research Center (SPARC)

Research Webpage
SPARC Webpage
Phone: 361-216-2800
  • Education   
  • University of Toronto Department of Molecular and Medical Genetics, PhD
  • Howard Hughes Medical Institute, Pasadena, CA, Postdoc
  • University of California Center for Neurobiology of Learning and Memory, Fellowship
  • Research Interests   
  • Cooperative mechanisms of HIV and opioids in pain pathogenesis
  • Antiretroviral therapy and neuroinflammation in the CNS
  • Pathogenic mechanism of HIV-associated pain
  • Interplay of HIV-1 gp120 and opioids in astrocyte activation
  • Recent Publications   
  • PubMed Search
  • Watson Z, Tang SJ. Aberrant Synaptic Pruning in CNS Diseases: A Critical Player in HIV-Associated Neurological Dysfunction?. Cells. 2022 Jun 16;11(12):1943
  • Tang SJ. Reactive astrocytes in pain neural circuit pathogenesis. Curr Opin Neurobiol. 2022 Jun 16;75
  • Liu X, Bae C, Gelman BB, Chung JM, Tang SJ. A neuron-to-astrocyte Wnt5a signal governs astrogliosis during HIV-associated pain pathogenesis. Brain. 2022 Jan 18.
  • Shi Y, Yuan S, Tang SJ. Reactive Oxygen Species (ROS) are Critical for Morphine Exacerbation of HIV-1 gp120-Induced Pain. J Neuroimmune Pharmacol. 2021 Sep;16(3):581-591.
  • Kearns A, Jayasi J, Liu X, Wang J, Shi Y, Chung JM, La JH, Tang SJ, Bae C. Neuron Type-Dependent Synaptic Activity in the Spinal Dorsal Horn of Opioid-Induced Hyperalgesia Mouse Model. Front Synaptic Neurosci. 2021 Nov 18;13:748929.
  • Jie Z, Ko CJ, Wang H, Xie X, Li Y, Gu M, Zhu L, Yang JY, Gao T, Ru W, Tang SJ, Cheng X, Sun SC. Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway. Sci Adv. 2021 Sep 3;7(36)
  • Liu X, Liu BL, Yang Q, Zhou X, Tang S-J. Microglial ablation does not affect opioid-induced hyperalgesia in rodents. Pain. 2021 Jun 17.
  • Hankerd K, McDonough KE, Wang J, Tang SJ, Chung JM, La JH. Postinjury stimulation triggers a transition to nociplastic pain in mice. Pain. 2021 Jun 14
  • Zheng J, Ru W, Adolacion JR, Spurgat MS, Liu X, Yuan S, Liang RX, Dong J, Potter A, Potter SS, Varadarajan N, Tang S-J. Single-cell RNA-seq analysis reveals compartment-specific heterogeneity and plasticity of microglia. iScience. 2021 Feb 12;24(3):102186
  • Bush KM, Barber KR, Martinez JA, Tang S-J, Wairkar YP. Drosophila model of anti-retroviral therapy induced peripheral neuropathy and nociceptive hypersensitivity. Biol Open. 2021 Jan 27;10(1)
  • Shi Y, Yuan S, Tang S-J. Reactive oxygen species (ROS) are critical for morphine exacerbation of HIV-1 gp120-induced pain. J Neuroimmune Pharmacol. 2020 Aug 22
  • Recent Presentations   
  • Liu X, Liu B, Tang S-J. Neuroinflammatory mechanisms of morphine -induced hyperalgesia. Annual Meeting of the Society of NeuroImmune Pharmacology. April 10-13, 2019, Portland, USA
  • Watson Z, Zheng J, Spurgat M, Ru W, Tang S. Glia-mediated synapse pruning in HIV gp120 transgenic mice. Society for Neuroscience 2021