SleepTalker December 2021

  Expertscape's PubMed-based algorithms placed Jun Lin, MD, PhD, FASA in the top 1% of scholars writing about Postoperative Pain over the past 10 years, a level they label as "Expert." His expertise ranks in the top 0.46% of 79,601 published authors worldwide on Postoperative Pain from 2011 through 2021. Congratulations!

  Bahaa E. Daoud, MD has been selected to be a question writer for the American Board of Anesthesiology. He says to look out for some board and MOCA questions by him in the near future. Congratulations!

    

Stephen A. Vitkun, MD, MBA, PhD

  We are pleased to announce that the Anesthesia Technology Program has just completed an accreditation review and has received a 5 year accreditation by the Commission on Accreditation of Allied Health Education Programs (CAAHEP). Thank you to all for making our Anesthesia Technology Program a success!

Mustahsan VM, Anugu A, Komatsu DE, Kao I, Pentyala S. Biocompatible Customized 3D Bone Scaffolds Treated with CRFP, an Osteogenic Peptide. Bioengineering 2021,8,199

Srinivas Pentyala, PhD

    The idea of developing customized bone implants was inspired from the work that I did with my orthopedic colleagues while testing customized resection techniques for bone-tumor surgeries. These surgeries leave behind unconventional defects in the bone that can be filled only with specially made-to-order implants. I got the idea of developing biocompatible and biomimetic bone implants using 3D printing by incorporating the structural characteristics (trabecular and cortical) of the bone. My team (collaborators in Orthopedics and Mechanical Engineering Departments) developed cylindrical scaffolds (with trabecular and cortical structures obtained from CT scan images of the bone) using ABS and MED610 materials.

These scaffolds were seeded with stem cells which were induced to differentiate into bone cells by the addition of a bioinformatically discovered and validated Calcitonin Receptor Fragment peptide (CRFP). In earlier studies, we showed that CRFP enhances bone matrix production by osteoblasts and differentiates stem cells into osteoblasts. We also showed that treatment of osteoporotic animals with CRFP increases the trabecular density of the bone. (Two patents were issued on the osteogenic CRFP discover and SBU Intellectual Property Partners licensed this technology to Industry).

    The current Bioengineering paper demonstrates that when CRFP is used, cells seeded artificial 3D-printed scaffolds produce more bone matrix and this performs better biomechanically.

    We recently finished muscle pouch bone implantation model studies and are in the process of submitting this for peer review. Future segmental defect studies in animals are being planned where diaphysis segment of femoral bone will be resected and a CRFP enhanced 3D graft will be implanted. The ultimate goal of this work is to replace the resected tumor portion of the bone with CRFP treated artificial 3D bone implants for complete biointegration.

   Members of the department presented a record number (eight) of abstracts at the "virtual" annual meeting of the Society for Neuroscience. Nice goin'!

   Bahaa Daoud and his wife were married in October. They are living happily ever after with their 3 cats. Congratulations!

• Romeiser JL, Cavalcante J, Richman DC, Singh SM, Liang X, Pei A, Sharma S, Lazarus Z, Gan TJ, Bennett-Guerrero E. Comparing Email, SMS, and Concurrent Mixed Modes Approaches to Capture Quality of Recovery in the Perioperative Period: Retrospective Longitudinal Cohort Study. JMIR Form Res. 2021 Nov 4;5(11):e25209
• NeuroLINCS Consortium, Li J, Lim RG, Kaye JA, Dardov V, Coyne AN, Wu J, Milani P, Cheng A, Thompson TG, Ornelas L, Frank A, Adam M, Banuelos MG, Casale M, Cox V, Escalante-Chong R, Daigle JG, Gomez E, Hayes L, Holewenski R, Lei S, Lenail A, Lima L, Mandefro B, Matlock A, Panther L, Patel-Murray NL, Pham J, Ramamoorthy D, Sachs K, Shelley B, Stocksdale J, Trost H, Wilhelm M, Venkatraman V, Wassie BT, Wyman S, Yang S; NYGC ALS Consortium [including Dubnau, J], Van Eyk JE, Lloyd TE, Finkbeiner S, Fraenkel E, Rothstein JD, Sareen D, Svendsen CN, Thompson LM. An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients. iScience. 2021 Oct 12;24(11):103221
• Azpurua J, El-Karim EG, Tranquille M, Dubnau J. A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia. PLoS Genet. 2021 Nov 1;17(11):e1009882
• Maltsev DI, Mellanson KA, Belousov VV, Enikolopov GN, Podgorny OV. The bioavailability time of commonly used thymidine analogues after intraperitoneal delivery in mice: labeling kinetics in vivo and clearance from blood serum. Histochem Cell Biol. 2021 Nov 10
• Parikh PB, Romeiser JL, Dhautel B, Mitchell D, Holecek W 3rd, Bilfinger T, Poppers J, Bennett-Guerrero E. Predictors and impact of low diastolic blood pressure and widened pulse pressure following transcatheter aortic valve replacement. Cardiovasc Revasc Med. 2021 Oct 28
• Mustahsan VM, Anugu A, Komatsu DE, Kao I, Pentyala S. Biocompatible Customized 3D Bone Scaffolds Treated with CRFP, an Osteogenic Peptide. Bioengineering 2021,8,199
• Liu Q, Li R, Li Q, Luo B, Lin J, Lyu L. High levels of plasma S100A9 at admission indicate an increased risk of death in severe tuberculosis patients. J Clin Tuberc Other Mycobact Dis. 2021 Sep 13;25:100270