Kaczocha lab - Publications

LIPID METABOLISM
AND SIGNALING:
ROLES IN PAIN
AND INFLAMMATION
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FABP5 is expressed throughout the mammalian brain, most notably in brain astrocytes. We are actively exploring the role of FABPs as modulators of endocannabinoid signaling within the brain.

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Selected Publications
  • Azim S, Nicholson J, Rebecchi MJ, Galbavy W, Feng T, Reinsel R, Volkow ND, Benveniste H, Kaczocha M. Endocannabinoids and acute pain after total knee arthroplasty. Pain. 2015 Feb;156(2):341-347 [PubMed]
  • Elmes MW, Kaczocha M, Berger WT, Leung K, Ralph BP, Wang L, Sweeney JM, Miyauchi JT, Tsirka SE, Ojima I, Deutsch DG. Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD). J Biol Chem. 2015 Feb 9 [PubMed]
  • Nicholson J, Azim S, Rebecchi MJ, Galbavy W, Feng T, Reinsel R, Rizwan S, Fowler CJ, Benveniste H, Kaczocha M. Leptin Levels Are Negatively Correlated with 2-Arachidonoylglycerol in the Cerebrospinal Fluid of Patients with Osteoarthritis. PLoS One. 2015 Apr 2;10(4) [PubMed]
  • Sirrs S, van Karnebeek CD, Peng X, Shyr C, Tarailo-Graovac M, Mandal R, Testa D, Dubin D, Carbonetti G, Glynn SE, Sayson B, Robinson WP, Han B, Wishart D, Ross CJ, Wasserman WW, Hurwitz TA, Sinclair G, Kaczocha M. Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms. Orphanet J Rare Dis. 2015 Mar 28;10(1):38 [PubMed]
  • Galbavy W, Kaczocha M, Puopolo M, Liu L, Rebecchi MJ. Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. PLoS One. 2015 Aug 4;10(8) [PubMed]
  • Kaczocha M, Glaser ST, Maher T, Clavin B, Hamilton J, O'Rourke J, Rebecchi M, Puopolo M, Owada Y, Thanos PK. Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms. Mol Pain. 2015 Aug 28;11(1):52 [PubMed]
  • Chakraborty S, Rebecchi M, Kaczocha M, Puopolo M. Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons. J Physiol. 2015 Nov 13. [PubMed]
  • Peng X, Studholme K, Kanjiya MP, Luk J, Bogdan D, Elmes MW, Carbonetti G, Tong S, Gary Teng YH, Rizzo RC, Li H, Deutsch DG, Ojima I, Rebecchi MJ, Puopolo M, Kaczocha M. Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms. Mol Pain. 2017 Jan;13
  • Galbavy W, Lu Y, Kaczocha M, Puopolo M, Liu L, Rebecchi MJ. Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord. Immun Ageing. 2017 Apr 13;14:9
  • Hsu HC, Tong S, Zhou Y, Elmes MW, Yan S, Kaczocha M, Deutsch DG, Rizzo RC, Ojima I, Li H. The antinociceptive agent SBFI-26 binds to anandamide transporters FABP5 and FABP7 at two different sites. Biochemistry. 2017 Jul 11;56(27):3454-3462
  • Figueiredo A, Hamilton J, Marion M, Blum K, Kaczocha M, Haj-Dahmane S, Deutsch D, Thanos PK. Pharmacological Inhibition of Brain Fatty Acid Binding Protein Reduces Ethanol Consumption in Mice. J Reward Defic Syndr Addict Sci. 2017;3(2):21-27
  • Thanos PK, Clavin BH, Hamilton J, O'Rourke JR, Maher T, Koumas C, Miao E, Lankop J, Elhage A, Haj-Dahmane S, Deutsch D, Kaczocha M. Examination of the Addictive and Behavioral Properties of Fatty Acid-Binding Protein Inhibitor SBFI26. Front Psychiatry. 2016 Apr 5;7:54 [PubMed]
  • Schroeder F, McIntosh AL, Martin GG, Huang H, Landrock D, Chung S, Landrock KK, Dangott LJ, Li S, Kaczocha M, Murphy EJ, Atshaves BP, Kier AB. Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias. Lipids. 2016 Jun;51(6):655-76 [PubMed]
  • Martin GG, Chung S, Landrock D, Landrock KK, Huang H, Dangott LJ, Peng X, Kaczocha M, Seeger DR, Murphy EJ, Golovko MY, Kier AB, Schroeder F. FABP-1 gene ablation impacts brain endocannabinoid system in male mice. J Neurochem. 2016 Aug;138(3):407-22 [PubMed]
  • Martin GG, Chung S, Landrock D, Landrock KK, Dangott LJ, Peng X, Kaczocha M, Murphy EJ, Kier AB, Schroeder F. Female Mice are Resistant to FABP1 Gene Ablation-Induced Alterations in Brain Endocannabinoid Levels. Lipids. 2016 Sep;51(9):1007-20 [PubMed]
  • Peng X, Studholme K, Kanjiya MP, Luk J, Bogdan D, Elmes MW, Carbonetti G, Tong S, Gary Teng YH, Rizzo RC, Li H, Deutsch DG, Ojima I, Rebecchi MJ, Puopolo M, Kaczocha M. Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms. Mol Pain. 2017 Jan;13
  • Chakraborty S, Elvezio V, Kaczocha M, Rebecchi M, Puopolo M. Presynaptic inhibition of transient receptor potential vanilloid type 1 (TRPV1) receptors by norepinephrine in nociceptive neurons. J Physiol. 2017 Jan 17
  • Bogdan D, Falcone J, Kanjiya MP, Park SH, Carbonetti G, Studholme K, Gomez M, Lu Y, Elmes MW, Smietalo N, Yan S, Ojima I, Puopolo M, Kaczocha M.
    Fatty acid binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation.
    J Biol Chem. 2018 Apr 6;293(14):5295-5306.
  • Hamilton J, Marion M, Figueiredo A, Clavin BH, Deutsch D, Kaczocha M, Haj-Dahmane S, Thanos PK..
    Fatty acid binding protein deletion prevents stress-induced preference for cocaine and dampens stress-induced corticosterone levels..
    Synapse. 2018 Jun;72(6):e22031.
  • Kaczocha M, Azim S, Nicholson J, Rebecchi MJ, Lu Y, Feng T, Romeiser JL, Reinsel R, Rizwan S, Shodhan S, Volkow ND, Benveniste H..
    Intrathecal morphine administration reduces postoperative pain and peripheral endocannabinoid levels in total knee arthroplasty patients: a randomized clinical trial..
    BMC Anesthesiol. 2018 Feb 27;18(1):27.
  • Haj-Dahmane S, Shen RY, Elmes MW, Studholme K, Kanjiya MP, Bogdan D, Thanos PK, Miyauchi JT, Tsirka SE, Deutsch DG, Kaczocha M.
    Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses.
    Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3482-3487.
  • Luk J, Lu Y, Ackermann A, Peng X, Bogdan D, Puopolo M, Komatsu DE, Tong S, Ojima I, Rebecchi MJ, Kaczocha M.
    Contribution of diacylglycerol lipase beta to pain after surgery.
    J Pain Res. 2018 Mar 5;11:473-482.
  • Hamilton J, Koumas C, Clavin BH, Marion M, Figueiredo A, Gonzalez S, O'Rourke JR, Deutsch D, Kaczocha M, Haj-Dahmane S, Thanos PK.
    Fatty acid-binding proteins 5 and 7 gene deletion increases sucrose consumption and diminishes forced swim immobility time.
    Behav Pharmacol. 2018 Mar 21.
  • Elmes MW, Volpe AD, d'Oelsnitz S, Sweeney JM, Kaczocha M.
    Lipocalin-Type Prostaglandin D Synthase Is a Novel Phytocannabinoid-Binding Protein.
    Lipids. 2018 Mar;53(3):353-360.
  • Yan S, Elmes MW, Tong S, Hu K, Awwa M, Teng GYH, Jing Y, Freitag M, Gan Q, Clement T, Wei L, Sweeney JM, Joseph OM, Che J, Carbonetti GS, Wang L, Bogdan DM, Falcone J, Smietalo N, Zhou Y, Ralph B, Hsu HC, Li H, Rizzo RC, Deutsch DG, Kaczocha M, Ojima I.
    SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins.
    Eur J Med Chem. 2018 May 24;154:233-252.
  • Lu Y, Doroshenko M, Lauzadis J, Kanjiya MP, Rebecchi M, Kaczocha M, Puopolo M.
    Presynaptic inhibition of primary nociceptive signals to dorsal horn lamina I neurons by dopamine.
    J Neurosci. 2018 Aug 24.
  • Azim S, Nicholson J, Rebecchi MJ, Galbavy W, Feng T, Rizwan S, Reinsel RA, Kaczocha M, Benveniste H.
    Interleukin-6 and leptin levels are associated with preoperative pain severity in patients with osteoarthritis but not with acute pain after total knee arthroplasty.
    Knee. 2018 Jan;25(1):25-33.
  • Elmes MW, Prentis LE, McGoldrick LL, Giuliano CJ, Sweeney JM, Joseph OM, Che J, Carbonetti GS, Studholme K, Deutsch DG, Rizzo RC, Glynn SE, Kaczocha M.
    FABP1 controls hepatic transport and biotransformation of Δ9-THC.
    Sci Rep. 2019 May 20;9(1):7588
  • Zhou Y, Elmes MW, Sweeney J, Joseph O, Che J, Hsu HC, Li H, Deutsch DG, Ojima I, Kaczocha M, Rizzo RC.
    Identification of Fatty Acid Binding Protein 5 Inhibitors Through Similarity-based Screening.
    Biochemistry. 2019 Sep 20.
  • Carbonetti G, Wilpshaar T, Kroonen J, Studholme K, Converso C, d'Oelsnitz S, Kaczocha M.
    FABP5 coordinates lipid signaling that promotes prostate cancer metastasis.
    Sci Rep. 2019 Dec 12;9(1):18944.
  • Kim J, Bogdan DM, Elmes MW, Awwa M, Yan S, Che J, Lee G, Deutsch DG, Rizzo RC, Kaczocha M, Ojima I.
    Incarvillateine produces antinociceptive and motor suppressive effects via adenosine receptor activation.
    PLoS One. 2019 Jun 25;14(6):e0218619.
  • Carbonetti G, Converso C, Clement T, Wang C, Trotman LC, Ojima I, Kaczocha M.
    Docetaxel/cabazitaxel and fatty acid binding protein 5 inhibitors produce synergistic inhibition of prostate cancer growth.
    Prostate. 2020 Jan;80(1):88-98.
  • Lauzadis J, Liu H, Yong L, Rebecchi MJ, Kaczocha M, Puopolo M.
    Contribution of T-type calcium channels to spinal cord injury induced hyperexcitability of nociceptors.
    J Neurosci. 2020 Aug 24.
  • Miller S, Daily L, Dharla V, Gertsch J, Malamas MS, Ojima I, Kaczocha M, Ogasawara D, Straiker A.
    Endocannabinoid metabolism and transport as targets to regulate intraocular pressure.
    Exp Eye Res. 2020 Sep 23:108266.
  • O'Sullivan SE, Kaczocha M.
    FABP5 as a novel molecular target in prostate cancer.
    Drug Discov Today. 2020 Sep 20:S1359-6446.
  • Kaczocha M, Haj-Dahmane S.
    Mechanisms of Endocannabinoid Transport in the Brain.
    Br J Pharmacol. 2021 Mar 30.